CD28 蛋白, Mouse (130a.a, HEK293, Fc-His)

CD28 Protein, a crucial regulator of T-cell activation, promotes cell proliferation, cytokine production, and T-cell survival. It enhances IL4 and IL10 production when combined with TCR/CD3 ligation and CD40L costimulation. CD28 Protein exists as a disulfide-linked homodimer and interacts with DUSP14, CD80/B7-1, CD86/B7-2/B70, and GRB2 (By similarity). CD28 Protein, Mouse (130a.a, HEK293, Fc-His) is the recombinant mouse-derived CD28 protein, expressed by HEK293 , with C-hFc, C-6*His labeled tag. The total length of CD28 Protein, Mouse (130a.a, HEK293, Fc-His) is 130 a.a., with molecular weight of ~60.0 kDa.

CD28 蛋白是 T 细胞激活的关键参与者，参与诱导细胞增殖、细胞因子产生和促进 T 细胞存活。与 TCR/CD3 连接和 CD40L 共刺激相结合时，它可增强 T 细胞中 IL4 和 IL10 的产生。CD28 蛋白通过二硫键以同二聚体形式存在，并与 DUSP14 相互作用。它与 CD80/B7-1 和 CD86/B7-2/B70 结合，并且还与 GRB2 相互作用（通过相似性）。

Mouse

HEK293

C-hFc;C-6*His

P31041 (N20-K149)

12487  [NCBI]

NKILVKQSPLLVVDSNEVSLSCRYSYNLLAKEFRASLYKGVNSDVEVCVGNGNFTYQPQFRSNAEFNCDGDFDNETVTFRLWNLHVNHTDIYFCKIEFMYPPPYLDNERSNGTIIHIKEKHLCHTQSSPK

Approximately 60.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.