2. 重组蛋白
  3. Immune Checkpoint Proteins CD Antigens Fc Receptors
  4. Inhibitory Checkpoint Molecules T Cell CD Proteins NK Cell CD Proteins Macrophage CD Proteins Monocyte CD Proteins Dendritic Cell CD Proteins Fc-gamma Receptor
  5. FcγRIIIA/CD16a CD300a Fc gamma RIII/CD16
  6. Fc gamma RIIIA/CD16a 蛋白, Cynomolgus (HEK293, His)

Fc gamma RIIIA/CD16a 蛋白, Cynomolgus (HEK293, His)

目录号: HY-P7806
产品使用指南

FCGR3A 是一种免疫球蛋白 G Fc 部分的受体，可增强抗体依赖性细胞介导的细胞毒性和抗体依赖性病毒感染。FCGR3A 还是潜在的免疫致癌分子，与肿瘤免疫浸润水平有关。FCGR3A 常常用作前列腺癌 (PCa) 预后价值的生物标志物。Fc gamma RIIIA/CD16a 蛋白, Cynomolgus (HEK293, His) 是重组的 Fc gamma RIIIA/CD16a 蛋白，由 HEK293 表达，带有 C-6*His 标签。Fc gamma RIIIA/CD16a 蛋白, Cynomolgus (HEK293, His) 全长 186 个氨基酸，分子量为 30-40 kDa。

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描述

FCGR3A is a receptor for the Fc portion of immunoglobulin G that enhances antibody-dependent cell-mediated cytotoxicity and antibody-dependent viral infection. FCGR3A is also a potential immune oncogenic molecule and is related to the level of tumor immune infiltration. FCGR3A is often used as a biomarker with prognostic value in prostate cancer (PCa). Fc gamma RIIIA/CD16a Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived Fc gamma RIIIA/CD16a protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Fc gamma RIIIA/CD16a Protein, Cynomolgus (HEK293, His) is 186 a.a., with molecular weight of 30-40 kDa.
研究背景

FCGR3A is a receptor for the Fc portion of immunoglobulin G, an integral membrane glycoprotein expressed on natural killer (NK) cells anchored by a transmembrane peptide. Whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMNs), where the receptor is anchored via a phosphatidylinositol (PI) linkage. FCGR3A enhances antibody-dependent cell-mediated cytotoxicity and antibody-dependent viral infection. Differential analysis results of public databases show that FCGR3A is generally highly expressed in pan-cancers, and its expression has been confirmed to be related to the infiltration of multiple immune cells, the expression of multiple immune checkpoint genes and DNA mismatch repair genes in systemic cancers. There is a negative correlation between FCGR3A and DNA methylation levels. FCGR3A and HAVCR2 are highly expressed in PCa and are associated with BCR-free survival in PCa patients. Therefore, FCGR3A is a biomarker with potential prognostic value in prostate cancer (PCa). FCGR3A may also be an immuno-oncogenic molecule that correlates with the level of tumor immune infiltration and affects drug sensitivity. In addition, studies have found that FCGR3A gene duplications are associated with HIV-1 acquisition and that allelic variants in FCGR3A play a role in HIV-1 infection in infants and control susceptibility to HIV-1 infection.
种属

Cynomolgus
表达系统

HEK293
标签

C-6*His
蛋白编号

A0A140HDP8 (E21-G206)
基因 ID

102140945  [NCBI]
蛋白结构
N-term
CD16a (E21-G206)
Accession # A0A140HDP8
6*His
C-term
同用名
rCynFc-gamma receptor 3A/CD16a, His; Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A; CD16a Antigen; Fc-Gamma RIII-Alpha; Fc-Gamma RIII; Fc-gamma RIIIa; FcRIII; FcRIIIa; FcR-10; IgG Fc Receptor III-2; CD16a; FCGR3A; CD16A; FCG3; FCGR3; IGFR3
氨基酸序列

EDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTRWFHNESLISSQTSSYFIAAARVNNSGEYRCQTSLSTLSDPVQLEVHIGWLLLQAPRWVFKEEESIHLRCHSWKNTLLHKVTYLQNGKGRKYFHQNSDFYIPKATLKDSGSYFCRGLIGSKNVSSETVNITITQDLAVSSISSFFPPG

分子量

30-40 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Fc gamma RIIIA/CD16a Protein, Cynomolgus (HEK293, His) 相关分类

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