FOLR2 蛋白, Mouse (HEK293, His)

FOLR2 Protein, crucial for binding folate and its derivatives, facilitates their transport into cells with notable affinity under neutral pH. Upon endocytosis and exposure to slightly acidic pH, FOLR2 undergoes a conformational change, significantly reducing its affinity for folates and releasing them from the receptor, similar to other proteins. FOLR2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived FOLR2 protein, expressed by HEK293 , with C-His labeled tag. The total length of FOLR2 Protein, Mouse (HEK293, His) is 207 a.a., with molecular weight of 30-40 kDa.

FOLR2 蛋白在与叶酸和还原叶酸衍生物的结合中发挥着关键作用，促进 5-甲基四氢叶酸和叶酸类似物转运至细胞内空间。在中性 pH 条件下，它对叶酸和叶酸类似物表现出显着的亲和力。然而，在受体内吞作用时，暴露于弱酸性 pH 值会引起 FOLR2 的构象变化，导致其对叶酸的亲和力大幅降低，并随后从受体中释放，正如在类似蛋白质中观察到的那样。

Mouse

HEK293

C-His

Q05685 (R21-S227)

14276  [NCBI]

30-40 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.