2. 重组蛋白
  3. Enzymes & Regulators
  4. Oxidoreductases (EC 1)
  5. GPD1L 蛋白, Human (GST)

GPD1L 蛋白, Human (GST)

目录号: HY-P700390
产品使用指南

GPD1L 蛋白调节心脏钠电流，酶活性降低导致 3-磷酸甘油水平升高。这会激活 GPD1L 依赖性 SCN5A 磷酸化途径，可能导致钠电流减少。GPD1L 引起的 NAD(H) 平衡改变也可能导致心脏钠电流降低。GPD1L 蛋白, Human (GST) 是重组的 GPD1L 蛋白，由 E. coli 表达，带有 N-GST 标签。GPD1L 蛋白, Human (GST) 全长 351 个氨基酸，分子量为 65.4 kDa。

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100 μg   询价  

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描述

GPD1L protein regulates cardiac sodium current, with decreased enzymatic activity leading to elevated glycerol 3-phosphate levels. This activates the GPD1L-dependent SCN5A phosphorylation pathway, potentially resulting in reduced sodium current. Altered NAD(H) balance induced by GPD1L may also contribute to the decrease in cardiac sodium current. GPD1L Protein, Human (GST) is the recombinant human-derived GPD1L protein, expressed by E. coli, with N-GST labeled tag. The total length of GPD1L Protein, Human (GST) is 351 a.a., with molecular weight of 65.4 kDa.
研究背景

GPD1L蛋白参与心脏钠电流的调节。其酶活性降低导致 3-磷酸甘油水平升高，激活 DPD1L 依赖性 SCN5A 磷酸化途径，可能导致钠电流减少。此外，GPD1L 引起的 NAD(H) 平衡变化可能导致心脏钠电流降低。
种属

Human
表达系统

E. coli
标签

N-GST
蛋白编号

Q8N335 (M1-T351)
基因 ID
蛋白结构
N-term
GST
GPD1L (M1-T351)
Accession # Q8N335
C-term
同用名
GPD1L; glycerol-3-phosphate dehydrogenase 1-like; glycerol-3-phosphate dehydrogenase 1-like protein; KIAA0089;
氨基酸序列

MAAAPLKVCIVGSGNWGSAVAKIIGNNVKKLQKFASTVKMWVFEETVNGRKLTDIINNDHENVKYLPGHKLPENVVAMSNLSEAVQDADLLVFVIPHQFIHRICDEITGRVPKKALGITLIKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCETTIGSKVMENGLLFKELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAFARIFCKGQVSTATFLESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQGPQTSAEVYRILKQKGLLDKFPLFTAVYQICYESRPVQEMLSCLQSHPEHT

分子量

65.4 kDa
纯度

Greater than 90% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

GPD1L Protein, Human (GST) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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