2. 重组蛋白
  3. Enzymes & Regulators
  4. Lyases (EC 4)
  5. GUCY2C/Guanylyl cyclase C 蛋白, Human (HEK293, N-His)

GUCY2C/Guanylyl cyclase C 蛋白, Human (HEK293, N-His)

目录号: HY-P700415
产品使用指南

GUCY2C 是一种鸟苷酸环化酶，催化 GTP 合成 cGMP，并作为大肠杆菌热稳定肠毒素的受体，刺激表达哺乳动物细胞中 cGMP 的积累。此外，内源性肽鸟苷蛋白和尿鸟苷蛋白可激活 GUCY2C。研究证实，这种多方面的作用强调了细胞信号传导中复杂的调节机制以及 GUCY2C 对各种刺激的反应。GUCY2C/Guanylyl cyclase C 蛋白, Human (HEK293, N-His) 是重组的 GUCY2C/鸟苷酸环化酶 C 蛋白，由 HEK293 表达，带有 N-10*His 标签。GUCY2C/Guanylyl cyclase C 蛋白, Human (HEK293, N-His) 全长 407 个氨基酸，分子量为 49.6 kDa。

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描述

GUCY2C, a guanylyl cyclase, catalyzes cGMP synthesis from GTP and acts as a receptor for E. coli heat-stable enterotoxin, stimulating cGMP accumulation in expressing mammalian cells. Additionally, endogenous peptides guanylin and uroguanylin activate GUCY2C. This multifaceted role underscores intricate regulatory mechanisms in cellular signaling and GUCY2C's responsiveness to various stimuli, as confirmed by studies. GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, N-His) is the recombinant human-derived GUCY2C/Guanylyl cyclase C protein, expressed by HEK293 , with N-10*His labeled tag. The total length of GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, N-His) is 407 a.a., with molecular weight of 49.6 kDa.
研究背景

研究证明，GUCY2C 是一种鸟苷酸环化酶，可作为 GTP 合成环 (cGMP) 的催化剂。此外，该蛋白还充当大肠杆菌热稳定肠毒素的受体，其中肠毒素显着刺激表达 GUCY2C 的 cin 哺乳动物细胞的积累。此外，GUCY2C 被内源性肽、鸟苷蛋白和尿鸟苷蛋白激活。这种多方面的作用强调了细胞信号传导中涉及 GUCY2C 的复杂调节机制及其对各种刺激的反应。
种属

Human
表达系统

HEK293
标签

N-10*His
蛋白编号

P25092 (S24-Q430)
基因 ID
蛋白结构
N-term
10*His
GUCY2C (S24-Q430)
Accession # P25092
C-term
同用名
Guanylyl cyclase C; GC-C; STAR; GUCY2C; GUC2C; STA receptor; DIAR6; EC 4.6.1; GCC; GUC2CEC 4.6.1.2; MUCIL
氨基酸序列

SQVSQNCHNGSYEISVLMMGNSAFAEPLKNLEDAVNEGLEIVRGRLQNAGLNVTVNATFMYSDGLIHNSGDCRSSTCEGLDLLRKISNAQRMGCVLIGPSCTYSTFQMYLDTELSYPMISAGSFGLSCDYKETLTRLMSPARKLMYFLVNFWKTNDLPFKTYSWSTSYVYKNGTETEDCFWYLNALEASVSYFSHELGFKVVLRQDKEFQDILMDHNRKSNVIIMCGGPEFLYKLKGDRAVAEDIVIILVDLFNDQYFEDNVTAPDYMKNVLVLTLSPGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKIFLENGENITTPKFAHAFRNLTFEGYDGPVTLDDWGDVDSTMVLLYTSVDTKKYKVLLTYDTHVNKTYPVDMSPTFTWKNSKLPNDITGRGPQ

分子量

49.6 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

GUCY2C/Guanylyl cyclase C Protein, Human (HEK293, N-His) 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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