1. 重组蛋白
  2. Biotinylated Proteins
  3. HLA-G Complex Tetramer 蛋白, Rhesus Macaque (HEK293, His-Avi)

HLA-G Complex Tetramer 蛋白, Rhesus Macaque (HEK293, His-Avi)

目录号: HY-P77692
产品使用指南

HLA-G 是 MHC I 类家族的一部分,通过向细胞毒性 T 细胞和自然杀伤细胞呈递抗原,在免疫调节中发挥着关键作用。与其他 MHC I 类分子不同,它表现出有限的多态性和组织特异性表达,包括在免疫豁免位点和胎盘中。它的表达与免疫耐受相关,可以防止过度的免疫反应。研究 HLA-G 机制可以深入了解免疫相关疾病和免疫反应调节的潜在治疗策略。HLA-G Complex Tetramer 蛋白, Rhesus Macaque (HEK293, His-Avi) 是重组的蛋白二聚体复合物,包含 HLA-G 和 B2M/Beta-2 microglobulin Protein,由 HEK293 表达,带有 C-Avi, C-His 标签,和 RIIPRHLQL 肽。HLA-G Complex Tetramer 蛋白, Rhesus Macaque (HEK293, His-Avi),分子量为 260-265 kDa。

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描述

The HLA-G, part of the MHC class I family, is pivotal in immune regulation by presenting antigens to cytotoxic T cells and natural killer cells. Distinct from other MHC class I molecules, it shows limited polymorphism and tissue-specific expression, including in immune-privileged sites and the placenta. Linked to immune tolerance, its expression guards against excessive immune responses. Investigating HLA-G mechanisms offers insights into immune-related disorders and potential therapeutic strategies for immune response modulation. HLA-G Complex Tetramer Protein, Rhesus Macaque (HEK293, His-Avi) is a recombinant protein dimer complex containing HLA-G and B2M/Beta-2 microglobulin Protein, expressed by HEK293 , with C-Avi, C-His labeled tag and RIIPRHLQL peptide. HLA-G Complex Tetramer Protein, Rhesus Macaque (HEK293, His-Avi), has molecular weight of 260-265 kDa.

研究背景

HLA-G 属于 MHC I 类家族。它是免疫系统的重要组成部分,在免疫调节中发挥着重要作用。该蛋白参与将抗原呈递给细胞毒性 T 细胞和自然杀伤细胞,从而影响免疫反应。与其他 MHC I 类分子相比,HLA-G 是独特的,因为它在某些组织(包括胎盘和免疫豁免位点)中表现出有限的多态性和表达。它的表达与免疫耐受和防止过度免疫反应有关。了解 HLA-G 功能的机制可以深入了解免疫相关疾病,并有可能开发出调节免疫反应的治疗策略。

种属

Rhesus Macaque

表达系统

HEK293

标签

C-Avi;C-His

蛋白编号

O02948 (G25-T305)&Q6V7J5 (I21-M119)&RIIPRHLQL

基因 ID

100187576  [NCBI]&712428  [NCBI]

同用名
HLA G antigen; sHLA-G; b2 microglobulin; HLA G; HLAG; HLA-G; MHC Class I Antigen G; MHC class Ib antigen; MHC-G; sHLA-G
分子量

260-265 kDa

纯度

Greater than 95% as determined by Tris-Bis PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

HLA-G Complex Tetramer Protein, Rhesus Macaque (HEK293, His-Avi) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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产品名称:
HLA-G Complex Tetramer Protein, Rhesus Macaque (HEK293, His-Avi)
目录号:
HY-P77692
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