HNRNPA2B1 蛋白, Mouse (His-SUMO, Myc)

The HNRNPA2B1 protein is an important heterogeneous nuclear ribonucleoprotein (hnRNP) that plays a key role in RNA processing and transport. It forms hnRNP particles that compact and stabilize transcripts to influence various cellular functions, including transcription, mRNA processing, nuclear export, localization, translation, and mRNA stability. HNRNPA2B1 Protein, Mouse (His-SUMO) is the recombinant mouse-derived HNRNPA2B1 protein, expressed by E. coli , with N-10*His, N-SUMO, C-Myc labeled tag. The total length of HNRNPA2B1 Protein, Mouse (His-SUMO) is 353 a.a., with molecular weight of ~57.4 kDa.

HNRNPA2B1 蛋白是一种异质核核糖核蛋白 (hnRNP)，在 RNA 加工和运输中发挥着关键作用。它与新生的前 mRNA 结合，参与 hnRNP 颗粒的形成，从而压缩和稳定转录本，最大限度地减少缠结和打结。这种包装过程影响各种细胞功能，包括转录、mRNA 前体加工、RNA 核输出、亚细胞定位、mRNA 翻译和成熟 mRNA 的稳定性。HNRNPA2B1在细胞核内与多个hnRNP和异质核RNA形成hnRNP颗粒。值得注意的是，在少突胶质细胞和神经元中，它通过识别并结合选定 mRNA 上的 A2RE 或 A2RE11 序列基序，促进特定 mRNA 转运至细胞质。除了 mRNA 运输之外，HNRNPA2B1 还结合端粒 DNA 序列，保护它们免受核酸内切酶消化，并充当 pri-miRNA 上 N6-甲基腺苷 (m6A) 标记的“阅读器”，促进 pri-miRNA 加工和 miRNA 分选到外泌体中。此外，它还充当 mRNA 剪接的调节剂，影响丙酮酸激酶 PKM 等基因的剪接。此外，HNRNPA2B1 还参与先天免疫反应的激活、感知病毒 DNA 以及易位到细胞质以激活 TBK1-IRF3 途径。这些不同的功能凸显了 HNRNPA2B1 在细胞过程中的多功能性。

Mouse

E. coli

N-10*His;N-SUMO;C-Myc

O88569 (M1-Y353)

53379  [NCBI]

MEKTLETVPLERKKREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGGGNFGGSPGYGGGRGGYGGGGPGYGNQGGGYGGGYDNYGGGNYGSGSYNDFGNYNQQPSNYGPMKSGNFGGSRNMGGPYGGGNYGPGGSGGSGGYGGRSRY

Approximately 57.4 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm sterile filtered PBS,6% Trehalose, pH 7.4

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.