IDO 蛋白, Mouse (His)

IDO Protein, an enzyme, is involved in the metabolism of tryptophan. Dysregulation of IDO Protein has been linked to immune escape mechanisms and tumor progression. Targeting IDO Protein may provide potential therapeutic interventions in cancer by modulating tryptophan metabolism, enhancing immune responses, and inhibiting tumor growth. IDO Protein, Mouse (His) is the recombinant mouse-derived IDO protein, expressed by E. coli , with N-6*His labeled tag. The total length of IDO Protein, Mouse (His) is 407 a.a., with molecular weight of 40-50 kDa.

IDO 蛋白是启动和调节犬尿氨酸途径中必需氨基酸色氨酸分解代谢的关键催化剂。它的关键作用超出了新陈代谢，包括积极参与外周免疫耐受，通过避免不受限制的免疫反应引起的自身免疫和免疫病理学来维持体内平衡。值得注意的是，色氨酸的缺乏会阻碍T淋巴细胞的分裂，而色氨酸分解代谢物的积累会诱导T细胞凋亡并促进调节性T细胞的分化。此外，IDO 还可作为抗肿瘤免疫的有效抑制剂，并通过剥夺细胞内病原体的色氨酸来限制其生长，从而发挥至关重要的作用。此外，IDO 对于保护胎儿免受母体免疫排斥至关重要，突显了其对免疫调节和细胞平衡的多种贡献。

Mouse

E. coli

N-6*His

P28776 (M1-P407)

15930  [NCBI]

MALSKISPTEGSRRILEDHHIDEDVGFALPHPLVELPDAYSPWVLVARNLPVLIENGQLREEVEKLPTLSTDGLRGHRLQRLAHLALGYITMAYVWNRGDDDVRKVLPRNIAVPYCELSEKLGLPPILSYADCVLANWKKKDPNGPMTYENMDILFSFPGGDCDKGFFLVSLLVEIAASPAIKAIPTVSSAVERQDLKALEKALHDIATSLEKAKEIFKRMRDFVDPDTFFHVLRIYLSGWKCSSKLPEGLLYEGVWDTPKMFSGGSAGQSSIFQSLDVLLGIKHEAGKESPAEFLQEMREYMPPAHRNFLFFLESAPPVREFVISRHNEDLTKAYNECVNGLVSVRKFHLAIVDTYIMKPSKKKPTDGDKSEEPSNVESRGTGGTNPMTFLRSVKDTTEKALLSWP

40-50 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.