1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Interleukin & Receptors
  4. IL-11
  5. IL-11 蛋白, Human (P.pastoris)

IL-11 蛋白, Human (P.pastoris)

目录号: HY-P70425
COA 产品使用指南

IL-11蛋白是一种细胞因子,可刺激造血干细胞和巨核细胞祖细胞的增殖,从而导致血小板生成增加。IL-11 蛋白, Human (P.pastoris) 是重组的 IL-11 蛋白,由 P. pastoris 表达,不带标签。IL-11 蛋白, Human (P.pastoris) 全长 177 个氨基酸,分子量约为 ~19.0 kDa。

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规格 价格 是否有货 数量
10 μg ¥1450 In-stock
50 μg ¥4000 In-stock
100 μg   询价  

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描述

IL-11 protein is a cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells, leading to increased platelet production. IL-11 Protein, Human (P.pastoris) is the recombinant human-derived IL-11 protein, expressed by P. pastoris , with tag free. The total length of IL-11 Protein, Human (P.pastoris) is 177 a.a., with molecular weight of ~19.0 kDa.

研究背景

IL-11 蛋白作为一种多方面的细胞因子出现,协调重要的生物过程。它刺激造血干细胞和巨核细胞祖细胞的增殖,最终导致巨核细胞的成熟和增加血小板的产生。此外,IL-11 通过促进肝细胞增殖以应对损伤,从而在肝再生中发挥关键作用。它与由 IL6ST 和 IL11RA 组成的受体复合物结合,启动信号级联反应,促进细胞增殖。这种相互作用激活细胞内蛋白激酶并触发 STAT3 的磷酸化。值得注意的是,IL-11 在信号传导方式上表现出多功能性:它在与膜结合的 IL11RA 和 IL6ST 相互作用时参与“经典信号传导”,或者,当与可溶性 IL11RA 结合到 IL6ST 时,它参与“反式信号传导”。IL-11 及其受体 IL11RA 和 IL6ST 之间错综复杂的相互作用,形成了一个多聚体信号复合物,对多种生理反应具有深远的影响。

种属

Human

表达系统

P. pastoris

标签

Tag Free

蛋白编号

P20809 (G23-L199)

基因 ID
蛋白结构
N-term
IL-11 (G23-L199)
Accession # P20809
C-term
同用名
Interleukin-11; IL-11; Adipogenesis Inhibitory Factor; AGIF; Oprelvekin; IL11
氨基酸序列

GPPPGPPRVSPDPRAELDSTVLLTRSLLADTRQLAAQLRDKFPADGDHNLDSLPTLAMSAGALGALQLPGVLTRLRADLLSYLRHVQWLRRAGGSSLKTLEPELGTLQARLDRLLRRLQLLMSRLALPQPPPDPPAPPLAPPSSAWGGIRAAHAILGGLHLTLDWAVRGLLLLKTRL

分子量

Approximately 19.0 kDa

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 2% Glycine, pH 7.2.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US;may vary elsewhere.

文件资料

IL-11 Protein, Human (P.pastoris) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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目录号:
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