IL-23R 蛋白, Human (HEK293, mFc)

IL-23R Protein, critical in immune response, forms the interleukin-23 receptor by associating with IL12RB1. Binding to IL23, it activates T-cells, NK cells, and potentially macrophage/myeloid cells through Jak-Stat signaling. IL23, involved in innate and adaptive immunity, contributes to acute infection response. Associated with autoimmune diseases and tumorigenesis, IL-23R, in the presence of IL12RB1, forms a heterodimeric IL-23 receptor, interacting with JAK2 and activating STAT3. IL-23R Protein, Human (HEK293, mFc) is the recombinant human-derived IL-23R protein, expressed by HEK293, with C-mFc labeled tag. The total length of IL-23R Protein, Human (HEK293, mFc) is 332 a.a., with molecular weight of 80-115 kDa.

IL-23R 蛋白在免疫反应中发挥着关键作用，因为它通过与 IL12RB1 结合形成白细胞介素 23 受体。它与 IL23 结合，并通过 Jak-Stat 信号级联触发 T 细胞、NK 细胞以及潜在的某些巨噬细胞/骨髓细胞的激活。IL23 参与先天性免疫和适应性免疫，并且可能有助于外周组织对感染的急性反应。此外，IL23 与自身免疫性炎症性疾病有关，并已被证明在肿瘤发生中发挥重要作用。当 IL12RB1 存在时，IL-23R 形成异二聚体，充当 IL-23 受体。它与 JAK2 相互作用，并且在 IL23 存在的情况下激活 STAT3。

1.Immobilized Human IL-23 alpha&Mouse IL-12, His Tag at 5 μg/mL (100 μl/Well) on the plate. Dose response curve for Human IL-23R, mFc Tag with the EC₅₀ of 0.33 μg/mL determined by ELISA.
2.Immobilized Biotinylated Human IL-23 alpha&IL-12 beta, His Tag at 2 μg/mL (100 μl/well) on the streptavidin precoated plate (5 μg/mL). Dose response curve for Human IL-23R, mFc Tag with the EC₅₀ of 11.1 ng/mL determined by ELISA.

Human

HEK293

C-mFc

Q5VWK5 (G24-G355)

149233  [NCBI]

80-115 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 5% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.