1. 重组蛋白
  2. Cytokines and Growth Factors
  3. Interleukin & Receptors
  4. IL-23 Receptor
  5. IL-23R 蛋白, Rat (HEK293, His)

IL-23R 蛋白, Rat (HEK293, His)

目录号: HY-P73885
COA 产品使用指南

IL-23R 蛋白在免疫反应中至关重要,通过与 IL12RB1 结合形成白细胞介素 23 受体。它与 IL23 结合,通过 Jak-Stat 信号传导激活 T 细胞、NK 细胞和潜在的巨噬细胞/骨髓细胞。IL-23R 与自身免疫性疾病和肿瘤发生相关,在 IL12RB1 存在的情况下,形成异二聚体 IL-23 受体,与 JAK2 相互作用并激活 STAT3。IL-23R 蛋白, Rat (HEK293, His) 是重组的 IL-23R 蛋白,由 HEK293 表达,带有 C-His 标签。IL-23R 蛋白, Rat (HEK293, His) 全长 367 个氨基酸,分子量约为 ~43.8 kDa。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

IL-23R Protein, critical in immune response, forms the interleukin-23 receptor by associating with IL12RB1. Binding to IL23, it activates T-cells, NK cells, and potentially macrophage/myeloid cells through Jak-Stat signaling. Associated with autoimmune diseases and tumorigenesis, IL-23R, in the presence of IL12RB1, forms a heterodimeric IL-23 receptor, interacting with JAK2 and activating STAT3. IL-23R Protein, Rat (HEK293, His) is the recombinant rat-derived IL-23R protein, expressed by HEK293 , with C-His labeled tag. The total length of IL-23R Protein, Rat (HEK293, His) is 367 a.a., with molecular weight of ~43.8 kDa.

研究背景

白细胞介素 23 受体 (IL-23R) 在免疫反应中发挥着关键作用,因为它通过与 IL12RB1 结合形成白细胞介素 23 受体。它与 IL23 结合,并通过 Jak-Stat 信号级联触发 T 细胞、NK 细胞以及潜在的某些巨噬细胞/骨髓细胞的激活。IL23 参与先天性免疫和适应性免疫,并且可能有助于外周组织对感染的急性反应。此外,IL23 与自身免疫性炎症性疾病有关,并已被证明在肿瘤发生中发挥重要作用。当 IL12RB1 存在时,IL-23R 形成异二聚体,充当 IL-23 受体。它与 JAK2 相互作用,并且在 IL23 存在的情况下激活 STAT3。IL23/IL-23R 促进 T 辅助细胞 1 和 T 辅助细胞 17 的分化和促炎细胞因子的分泌,从而增加宿主的杀菌活性[1][2][3]

种属

Rat

表达系统

HEK293

标签

C-His

蛋白编号

XP_003753958 (M1-D367)

基因 ID

689932  [NCBI]

蛋白结构
N-term
IL-23R (M1-D367)
Accession # XP_003753958
His
C-term
同用名
Interleukin 23 receptor; IL 23R; IL-23 receptor; IL-23R
分子量

Approximately 43.8 kDa

纯度

Greater than 85% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料

IL-23R Protein, Rat (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
IL-23R Protein, Rat (HEK293, His)
目录号:
HY-P73885
需求量: