Jagged-1/JAG1 蛋白, Mouse (Myc, His-SUMO)

Jagged-1/JAG1 protein is a multifunctional ligand that binds to multiple Notch receptors and mediates Notch signaling. It influences cell fate decisions during hematopoiesis, spans early and late mammalian cardiovascular development, and regulates myoblast differentiation. Jagged-1/JAG1 Protein, Mouse (Myc, His-SUMO) is the recombinant mouse-derived Jagged-1/JAG1 protein, expressed by E. coli , with C-Myc, N-SUMO, N-10*His labeled tag. The total length of Jagged-1/JAG1 Protein, Mouse (Myc, His-SUMO) is 302 a.a., with molecular weight of ~53.6 kDa.

Jagged-1 (JAG1) 作为一种多功能配体，与多个 Notch 受体结合并参与 Notch 信号传导的介导。它的参与延伸到造血过程中细胞命运决定的潜在作用，并跨越哺乳动物心血管发育的早期和晚期阶段。此外，JAG1 展示了调节成肌细胞分化的能力，强调了其对不同细胞过程的调节影响。此外，它可能在成纤维细胞生长因子诱导的血管生成的调节中发挥作用。通过与 NOTCH1、NOTCH2 和 NOTCH3 的相互作用，JAG1 有助于 Notch 信号传导的复杂协调，突显其在细胞反应和发育途径中的重要性。

Mouse

E. coli

C-Myc;N-SUMO;N-10*His

Q9QXX0 (33G-334E)

16449  [NCBI]

GQFELEILSMQNVNGELQNGNCCGGVRNPGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFGSGSTPVIGGNTFNLKASRGNDRNRIVLPFSFAWPRSYTLLVEAWDSSNDTIQPDSIIEKASHSGMINPSRQWQTLKQNTGIAHFEYQIRVTCDDHYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPDCNKAICRQGCSPKHGSCKLPGDCRCQYGWQGLYCDKCIPHPGCVHGTCNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNRGTCSNTGPDKYQCSCPEGYSGPNCE

Approximately 53.6 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized after extensive dialysis against solution in PBS, 6% Trehalose, pH 7.4 or 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.