LECT1 蛋白, Human (HEK293, Fc)

LECT1 Protein, a bifunctional growth regulator, stimulates cultured chondrocyte growth with FGF, promoting cartilage expansion. Conversely, it inhibits vascular endothelial cell growth, contrasting its effect on endothelial proliferation. This dual role may coordinate cartilage growth and vascular invasion during endochondral bone development, where LECT1 is implicated in rapid cartilage growth preceding bone replacement. Additionally, LECT1 acts as an antiangiogenic factor in cardiac valves, suppressing neovascularization and highlighting its intricate involvement in chondrogenesis and angiogenesis regulation. LECT1 Protein, Human (HEK293, Fc) is the recombinant human-derived LECT1 protein, expressed by HEK293, with N-hFc labeled tag. The total length of LECT1 Protein, Human (HEK293, Fc) is 119 a.a., with molecular weight of ~42.1 kDa.

LECT1 蛋白作为双功能生长调节剂，在细胞生长调节中发挥双重作用。它在碱性成纤维细胞生长因子 (FGF) 存在的情况下刺激培养的软骨细胞的生长，表明它具有促进软骨扩张的作用。相反，LECT1 抑制培养的血管内皮细胞的生长，突出了其对内皮细胞增殖的对比作用。这种双功能性质可能有助于软骨内骨发育过程中软骨生长和血管侵袭的协调调节，其中 LECT1 参与软骨在被骨替代之前的快速生长。此外，LECT1 作为心脏瓣膜中的抗血管生成因子，通过抑制体外管形成和内皮细胞动员来抑制新血管形成。这些多方面的活动强调了 LECT1 在软骨生成和血管生成过程的调节中的复杂参与。

Human

HEK293

N-hFc

O75829 (E215-V333)

11061  [NCBI]

Approximately 42.1 kDa

Greater than 90% as determined by reducing SDS-PAGE

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Normally 5 % - 8 % trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.