MBP 蛋白, Mouse (His)

MBP proteins, especially the classical isoforms 4-13, dominate myelin membranes in the central nervous system and are critical for myelination and stability. In contrast, the non-canonical isoform 1-3/Golli-MBP may be involved in early brain development and contribute to transcriptional complexes that influence multiple cellular processes. MBP Protein, Mouse (His) is the recombinant mouse-derived MBP protein, expressed by E. coli , with N-His labeled tag. The total length of MBP Protein, Mouse (His) is 250 a.a., with molecular weight of 30-40 kDa.

经典的 MBP 亚型（亚型 4-亚型 13）与 PLP 一起是中枢神经系统 (CNS) 髓鞘膜中的主要蛋白质成分，在髓鞘的形成和稳定中发挥着重要作用。相反，MBP 异构体的非经典组（异构体 1-异构体 3/Golli-MBP）可能特别参与大脑发育的早期阶段，即髓鞘形成之前。这些亚型可能作为转录复合物的组成部分发挥作用，有助于复杂的细胞过程。此外，非经典组的成员可能参与 T 细胞和神经细胞内的信号传导通路。差异剪接事件和可选的翻译后修饰产生的广泛异构体增加了复杂性，每种异构体都可能具有专门的功能。MBP 蛋白形成同二聚体，进一步发挥其多样化的功能作用。

Mouse

E. coli

N-His

P04370 (M1-R250)

17196  [NCBI]

30-40 kDa

Greater than 90% as determined by Tris-Bis PAGE.

溶液

Supplied as a 0.22 μm filtered solution of PBS, 1 mM DTT, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.