MIF 蛋白, Human (His)

The MIF protein is a pro-inflammatory cytokine that is critical for the innate immune response against bacterial pathogens. Its presence at sites of inflammation suggests a role in modulating macrophage function to promote host defense. MIF counteracts the anti-inflammatory effects of glucocorticoids. Although MIF exhibits tautomerase activity in vitro, its physiological substrates remain unknown, and the relevance of this activity to its cytokine function is unclear. MIF Protein, Human (His) is the recombinant human-derived MIF protein, expressed by E. coli, with N-6*His labeled tag. The total length of MIF Protein, Human (His) is 115 a.a., with molecular weight of 10-14 kDa.

MIF 蛋白是一种促炎细胞因子，在针对细菌病原体的先天免疫反应中发挥着至关重要的作用。它在炎症部位的表达表明它参与调节宿主防御中的巨噬细胞功能。MIF 抵消糖皮质激素的抗炎作用。尽管 MIF 在体外具有苯丙酮酸互变异构酶和多巴色素互变异构酶活性，但 MIF 的生理底物仍不清楚。目前尚不清楚互变异构酶活性是否与其细胞因子活性相关。

Human

E. coli

N-6*His

P14174 (M1-A115)

4282  [NCBI]

MPMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA

10-14 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液.

Supplied as a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl,50% Glycerol, pH 7.4.

<1 EU/μg, determined by LAL method.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.