2. 重组蛋白
  3. Immune Checkpoint Proteins CD Antigens Receptor Proteins
  4. Inhibitory Checkpoint Molecules NK Cell CD Proteins Platelet CD Proteins Erythrocyte CD Proteins Epithelial cell CD Proteins Endothelial cell CD Proteins Cell Adhesion Molecules (CAMs)
  5. Nectin-1/CD111 Immunoglobulin-like Cell Adhesion Molecules
  6. Nectin-1 蛋白, Mouse (HEK293, Fc)

Nectin-1 蛋白, Mouse (HEK293, Fc)

目录号: HY-P77468
产品使用指南

Nectin-1 在细胞粘附和突触发生中至关重要，可促进神经突生长，并可作为 α 疱疹病毒（包括 HSV-1、HSV-2 和伪狂犬病病毒）的受体。它促进病毒进入并参与同二聚化、与 NECTIN3 的反式异二聚化以及与 FGFR、AFDN 和 HSV 糖蛋白 D 的相互作用。Nectin-1 蛋白, Mouse (HEK293, Fc) 是重组的 Nectin-1 蛋白，由 HEK293 表达，带有 C-hFc 标签。Nectin-1 蛋白, Mouse (HEK293, Fc) 全长 354 个氨基酸，分子量约为 ~62.9 KDa。

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描述

Nectin-1 is critical in cell adhesion and synaptogenesis, promotes neurite outgrowth, and serves as a receptor for alphaherpesviruses, including HSV-1, HSV-2, and pseudorabies virus. It promotes viral entry and is involved in homodimerization, trans-heterodimerization with NECTIN3, and interactions with FGFR, AFDN, and HSV glycoprotein D. Nectin-1 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived Nectin-1 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of Nectin-1 Protein, Mouse (HEK293, Fc) is 354 a.a., with molecular weight of ~62.9 KDa.
研究背景

Nectin-1 是细胞粘附和突触发生的关键参与者，具有神经突生长促进活性，强调了其在神经发育过程中的重要性。Nectin-1 作为 α 疱疹病毒（包括 HSV-1、HSV-2 和伪狂犬病病毒）的受体，可促进病毒进入细胞。该蛋白参与顺式和反式同二聚化，还可以与 NECTIN3 形成反式异二聚体，启动对轴突-树突相互作用至关重要的点粘附连接的形成。此外，它与 FGFR1、FGFR2 和 FGFR3 以及 AFDN 的相互作用，与肌动蛋白细胞骨架建立了联系，有助于其发挥多种细胞作用。值得注意的是，Nectin-1 与 HSV 糖蛋白 D (gD) 相互作用，强调了它参与病毒感染过程。
种属

Mouse
表达系统

HEK293
标签

C-hFc
蛋白编号

Q9JKF6 (M1-A354)
基因 ID

58235  [NCBI]
蛋白结构
N-term
Nectin-1 (M1-A354)
Accession # Q9JKF6
hFc
C-term
同用名
Poliovirus Receptor-Related Protein 1; Herpes Virus Entry Mediator C; Herpesvirus Entry Mediator C; HveC; Herpesvirus Ig-Like Receptor; HIgR; Nectin-1; CD111; PVRL1; HVEC; PRR1
分子量

Approximately 62.9 kDa.
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Nectin-1 Protein, Mouse (HEK293, Fc) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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