1. 重组蛋白
  2. Enzymes & Regulators Ubiquitin Related Proteins
  3. Transferases (EC 2) Ubiquitin Enzymes
  4. E3 Ligases
  5. NOSIP 蛋白, Human

NOSIP 蛋白, Human

目录号: HY-P701597
产品使用指南

NOSIP 是一种 E3 泛素蛋白连接酶,在前脑、眼睛和面部的正常发育中发挥着关键作用。值得注意的是,它催化丝氨酸/苏氨酸蛋白磷酸酶 2A (PP2A) 催化亚基的单泛素化,特别是 PPP2CA/PPP2CB。NOSIP 蛋白, Human 是重组的 NOSIP 蛋白,由 E. coli 表达,不带标签。NOSIP 蛋白, Human 全长 300 个氨基酸。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

重组蛋白定制服务

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 μg   询价  
100 μg   询价  

* Please select Quantity before adding items.

  • 生物活性

  • 技术参数

  • 产品性质

  • 产品资料

描述

NOSIP is an E3 ubiquitin protein ligase that plays a key role in the normal development of the forebrain, eye, and face. Notably, it catalyzes the monoubiquitination of the serine/threonine protein phosphatase 2A (PP2A) catalytic subunit, specifically PPP2CA/PPP2CB. NOSIP Protein, Human is the recombinant human-derived NOSIP protein, expressed by E. coli , with tag free. The total length of NOSIP Protein, Human is 300 a.a., .

研究背景

NOSIP 是一种重要的 E3 泛素蛋白连接酶,对于前脑、眼睛和面部的正常发育至关重要。它通过催化丝氨酸/苏氨酸蛋白磷酸酶 2A (PP2A) 催化亚基 PPP2CA/PPP2CB 的单泛素化,在细胞过程中发挥关键作用。此外,NOSIP 通过诱导 NOS1 和 NOS3 易位至肌动蛋白细胞骨架,最终抑制其酶活性,从而充当一氧化氮生成的负调节因子。这种双重功能凸显了 NOSIP 在发育过程和一氧化氮信号传导调节中的重要性,强调了其在细胞稳态中的多功能作用。

种属

Human

表达系统

E. coli

标签

Tag Free

蛋白编号

Q9Y314 (T2-A301)

基因 ID

51070

蛋白结构
N-term
NOSIP (T2-A301)
Accession # Q9Y314
C-term
同用名
NOSIP; Nitric oxide synthase-interacting protein; E3 ubiquitin-protein ligase NOSIP; RING-type E3 ubiquitin transferase NOSIP; eNOS-interacting protein
纯度

Greater than 90% as determined by reducing SDS-PAGE.

内毒素含量

<1 EU/μg, determined by LAL method.

文件资料
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
NOSIP Protein, Human
目录号:
HY-P701597
需求量: