Nucleobindin-2 蛋白, Human

Nucleobindin-2 protein is a calcium-binding molecule that may contribute to calcium homeostasis and act as a non-receptor guanine nucleotide exchange factor. Its interaction with the guanine nucleotide-binding protein (G protein) α subunit GNAI3 suggests its role in activating the G protein signaling pathway. Nucleobindin-2 Protein, Human is the recombinant human-derived Nucleobindin-2 protein, expressed by E. coli , with tag free.

Nucleobindin-2 是一种与钙稳态有关的钙结合蛋白，作为非受体鸟嘌呤核苷酸交换因子，特异性地与鸟嘌呤核苷酸结合蛋白（G 蛋白）α 亚基 GNAI3 相互作用并激活它。除了在钙动力学中的作用外，Nucleobindin-2 还充当一种厌食肽，在调节食物摄入和能量稳态的下丘脑通路中发挥着重要作用，并以不依赖于瘦素的方式发挥作用。此外，这种蛋白质被认为具有潜在的高血压作用，通过直接影响外周动脉阻力来调节血压。参考文献强调了 Nucleobindin-2 在细胞过程中的多种作用，包括钙调节、食欲控制以及对心血管生理学的潜在贡献。

Human

E. coli

Tag Free

P80303-1 (V25-L106)

4925  [NCBI]

VPIDIDKTKVQNIHPVESAKIEPPDTGLYYDEYLKQVIDVLETDKHFREKLQKADIEEIKSGRLSKELDLVSHHVRTKLDEL

Approximately 10.0 kDa

Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of 10 mM Sodium Phosphate, pH 6.5.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.