OCIL/CLEC2D 蛋白, Human (HEK293, Fc-Avi)

OCIL/CLEC2D Protein, as a receptor for KLRB1, safeguards target cells from natural killer cell-mediated lysis. It not only inhibits osteoclast formation and bone resorption but also regulates interferon-gamma release, indicating its immune and bone-related regulatory functions. Additionally, OCIL/CLEC2D can bind high molecular weight sulfated glycosaminoglycans, suggesting its involvement in interactions with extracellular components. Existing as a homodimer with disulfide linkages, its oligomeric form plays a crucial role in mediating immune protection and bone homeostasis. OCIL/CLEC2D Protein, Human (HEK293, Fc-Avi) is the recombinant human-derived OCIL/CLEC2D protein, expressed by HEK293, with N-hFc, N-Avi labeled tag. The total length of OCIL/CLEC2D Protein, Human (HEK293, Fc-Avi) is 132 a.a., with molecular weight of 68-78 kDa.

OCIL/CLEC2D 蛋白作为 KLRB1 的受体，为靶细胞提供保护，防止自然杀伤细胞介导的裂解。它不仅能抑制破骨细胞形成和骨吸收，还能调节干扰素-γ的释放，显示出其在免疫反应和骨相关过程中的调节作用。此外，OCIL/CLEC2D 表现出结合高分子量硫酸化糖胺聚糖的能力，表明其参与与细胞外成分的相互作用。在结构上，它作为具有二硫键的同二聚体存在，强调其寡聚形式在介导与免疫保护和骨稳态相关的细胞功能中的重要性。

Human

HEK293

N-hFc;N-Avi

Q9UHP7-1 (R60-V191)

29121  [NCBI]

RANCHQEPSVCLQAACPESWIGFQRKCFYFSDDTKNWTSSQRFCDSQDADLAQVESFQELNFLLRYKGPSDHWIGLSREQGQPWKWINGTEWTRQFPILGAGECAYLNDKGASSARHYTERKWICSKSDIHV

68-78 kDa

Greater than 95% as determined by Tris-Bis PAGE.

无菌粉末.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.