PDGF-DD 蛋白, Mouse (His-SUMO)

PDGF-DD protein is an important growth factor that controls embryonic development, cell proliferation, migration, survival and chemotaxis, and has a potent mitogenic effect on mesenchymal cells. It plays a key role in wound healing and has carcinogenic potential, contributing to tumor formation. PDGF-DD Protein, Mouse (His-SUMO) is the recombinant mouse-derived PDGF-DD protein, expressed by E. coli , with N-His, N-SUMO labeled tag. The total length of PDGF-DD Protein, Mouse (His-SUMO) is 347 a.a., with molecular weight of ~66 kDa.

PDGF-DD 蛋白是控制胚胎发育、细胞增殖、迁移、存活和趋化性的关键生长因子。PDGF-DD 以其对间充质细胞的有效促有丝分裂作用而闻名，在伤口愈合中发挥着关键作用，有趣的是，它还具有能够诱导肿瘤形成的致癌潜力。它的影响延伸到血管生成过程中复杂的事件安排，促进巨噬细胞募集、间质压力升高和血管成熟。PDGF-DD 的参与在导致系膜增生性肾小球肾炎的过程的启动中值得注意，其特征是单核细胞和巨噬细胞的流入以及细胞外基质的产生。在结构上，PDGF-DD以通过二硫键连接的同二聚体存在，与PDGFRB同二聚体和PDGFRA和PDGFRB形成的异二聚体相互作用，从而形成其多功能的调节机制。

Mouse

E. coli

N-His;N-SUMO

Q925I7 (24T-370R)

71785  [NCBI]

TPQRASIKALRNANLRRDESNHLTDLYQREENIQVTSNGHVQSPRFPNSYPRNLLLTWWLRSQEKTRIQLSFDHQFGLEEAENDICRYDFVEVEEVSESSTVVRGRWCGHKEIPPRITSRTNQIKITFKSDDYFVAKPGFKIYYSFVEDFQPEAASETNWESVTSSFSGVSYHSPSITDPTLTADALDKTVAEFDTVEDLLKHFNPVSWQDDLENLYLDTPHYRGRSYHDRKSKVDLDRLNDDVKRYSCTPRNHSVNLREELKLTNAVFFPRCLLVQRCGGNCGCGTVNWKSCTCSSGKTVKKYHEVLKFEPGHFKRRGKAKNMALVDIQLDHHERCDCICSSRPPR

Approximately 66 kDa

Greater than 90% as determined by reducing SDS-PAGE.

无菌粉末

Lyophilized after extensive dialysis against solution in 10 mM Tris-HCl, 1 mM EDTA, 6% Trehalose, pH 8.0.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.