PGLYRP1/PGRP-S 蛋白, Human (HEK293, Fc)

The PGLYRP1/PGRP-S protein is critical to the innate immune system and serves as a model receptor that binds to Gram-positive bacterial PGN to exert bactericidal activity. It forms a complex with HSPA1A and induces programmed cell death in tumor cells. PGLYRP1/PGRP-S Protein, Human (HEK293, Fc) is the recombinant human-derived PGLYRP1/PGRP-S protein, expressed by HEK293 , with C-hFc labeled tag. The total length of PGLYRP1/PGRP-S Protein, Human (HEK293, Fc) is 175 a.a., with molecular weight of 50-65 kDa.

PGLYRP1/PGRP-S 蛋白是先天免疫系统的一个组成部分，在抗菌和抗肿瘤防御机制中发挥着至关重要的作用。作为模式受体，它与革兰氏阳性菌的胞壁肽聚糖 (PGN) 结合，发挥杀菌活性。此外，PGLYRP1 与热休克蛋白 HSPA1A 形成等摩尔复合物，通过激活 TNFR1 受体，在肿瘤细胞系中通过细胞凋亡和坏死性凋亡诱导程序性细胞死亡。它与 Ca(2+) 结合蛋白 S100A4 一起发挥作用，充当趋化剂，能够通过与免疫系统细胞上的趋化受体 CCR5 和 CXCR3 相互作用来诱导淋巴细胞运动。这种复合物还促进淋巴细胞的活化，增强其消除病毒感染和肿瘤细胞的能力。单核细胞表面细胞毒性的诱导需要与 TREM1 受体相互作用。PGLYRP1 通过二硫键形成同型二聚体，并与 HSPBP1、TNFRSF1A、S100A4 和 TREM1 等各种蛋白质相互作用，协调对其多种功能至关重要的相互作用网络。

Immobilized Human TREM1, His Tag at 5 μg/mL (100 μl/well) on the plate. Dose response curve for Human PGLYRP1, hFc Tag with the EC₅₀ of ≤0.32 μg/mL determined by ELISA.

Human

HEK293

C-hFc

O75594 (Q22-P196)

8993  [NCBI]

50-65 kDa

Greater than 95% as determined by reducing SDS-PAGE.

溶液

Supplied as a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.