2. 重组蛋白
  3. Enzymes & Regulators
  4. Protease Inhibitors
  5. Serpin (Protease Inhibitor)
  6. Serpin I2
  7. Serpin I2 蛋白, Human (HEK293, His)

Serpin I2 蛋白, Human (HEK293, His)

目录号: HY-P71039
产品使用指南

Serpin I2 蛋白是 serpin (丝氨酸蛋白酶抑制剂) 超家族的成员。Serpin I2 (pancpin) 是一种针对胰腺弹性蛋白酶和胰凝乳蛋白酶的抑制性丝氨酸蛋白酶抑制剂。Serpin I2在胰腺癌和乳腺癌中下调，并且在小鼠中缺失时与腺泡细胞凋亡和胰腺功能不全相关。Serpin I2 与屈光不正相关，具有进一步研究近视遗传易感性的潜力。Serpin I2 蛋白, Human (HEK293, His) 是重组的 丝氨酸蛋白酶抑制剂 I2 蛋白，由 HEK293 表达，带有 C-6*His 标签。Serpin I2 蛋白, Human (HEK293, His) 全长 387 个氨基酸，分子量为 44-60 kDa。

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规格 是否有货
50 μg   询价  
100 μg   询价  

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描述

Serpin I2 Protein, is a member of the serpin (serine protease inhibitor) superfamily. Serpin I2 (pancpin) is an inhibitory serpin targeting pancreatic elastase and chymotrypsin. Serpin I2 is downregulated in pancreatic and breast cancer, and associated with acinar cell apoptosis and pancreatic insufficiency when absent in mice. Serpin I2 is associated with refractive error and has the potential for further investigations of the genetic susceptibility to myopia research[1][2]. Serpin I2 Protein, Human (HEK293, His) is the recombinant human-derived Serpin I2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Serpin I2 Protein, Human (HEK293, His) is 387 a.a., with molecular weight of 44-60 kDa.
研究背景

Serpin I2 在反应中心环内含有 Met-Ser，这也存在于抗胰蛋白酶中。小鼠中 Serpin I2 缺陷会导致胰腺功能不全和腺泡细胞凋亡，导致 pequeno 表型发育不良，免疫细胞缺陷并缩短寿命[1]。
Serpin I2 多态性增加了屈光不正的易感性。Serpin I2 是进一步研究近视遗传易感性的有希望的候选者。Serpin I2 参与胰腺腺泡细胞，可能对控制葡萄糖代谢很重要[2]。
种属

Human
表达系统

HEK293
标签

C-6*His
蛋白编号

O75830 (S19-L405 )
基因 ID
蛋白结构
N-term
Serpin I2 (S19-L405 )
Accession # O75830
6*His
C-term
同用名
SERPINI2; Serpin I2; Myoepithelium-derived serine protease inhibitor; Pancreas-specific protein TSA2004; Peptidase inhibitor 14; PI-14; MEPI; PI14;
氨基酸序列

SRCSAQKNTEFAVDLYQEVSLSHKDNIIFSPLGITLVLEMVQLGAKGKAQQQIRQTLKQQETSAGEEFFVLKSFFSAISEKKQEFTFNLANALYLQEGFTVKEQYLHGNKEFFQSAIKLVDFQDAKACAEMISTWVERKTDGKIKDMFSGEEFGPLTRLVLVNAIYFKGDWKQKFRKEDTQLINFTKKNGSTVKIPMMKALLRTKYGYFSESSLNYQVLELSYKGDEFSLIIILPAEGMDIEEVEKLITAQQILKWLSEMQEEEVEISLPRFKVEQKVDFKDVLYSLNITEIFSGGCDLSGITDSSEVYVSQVTQKVFFEINEDGSEAATSTGIHIPVIMSLAQSQFIANHPFLFIMKHNPTESILFMGRVTNPDTQEIKGRDLDSL

分子量

44-60 kDa
纯度

Greater than 95% as determined by reducing SDS-PAGE.
内毒素含量

<1 EU/μg, determined by LAL method.
文件资料
产品使用指南 (1213 KB)

Serpin I2 Protein, Human (HEK293, His) 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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