SIRP gamma 蛋白, Cynomolgus (HEK293, Fc)

SIRP gamma Protein, a member of signal-regulatory protein (SIRP) family, is the only SIRP detected on T cells and activated NK cells. SIRP gamma can bind CD47, providing T cells and NK cells with a cell surface molecule capable of interacting with CD47. SIRP gamma-CD47 interaction mediates strong cell-cell adhesion and supports T cell-APC contact, enhancing antigen presentation and consequent T-cell proliferation and cytokine secretion. SIRP gamma Protein, Cynomolgus (HEK293, Fc) is the recombinant cynomolgus-derived SIRP gamma protein, expressed by HEK293 , with C-hFc labeled tag. The total length of SIRP gamma Protein, Cynomolgus (HEK293, Fc) is 360 a.a., with molecular weight of 69-79 kDa.

SIRP gamma (SIRPG) 是信号调节蛋白 (SIRP) 家族的成员，是唯一在 T 细胞和活化的 NK 细胞上检测到的 SIRP。它作为一种免疫球蛋白样细胞表面受体出现，证明了其在与 CD47 结合后介导细胞间粘附的作用。这种相互作用对于增强抗原特异性 T 细胞增殖和为 T 细胞激活提供共刺激信号至关重要。结果，SIRP gamma 与抗原呈递细胞上的 CD47 结合，突出了它在调节免疫反应中的作用。SIRP gamma-CD47 相互作用介导强大的细胞间粘附并支持 T 细胞-APC 接触，增强抗原呈递以及随后的 T 细胞增殖和细胞因子分泌^[1]。

Cynomolgus

HEK293

C-hFc

XP_028684116 (M1-H360)

716034  [NCBI]

69-79 kDa

Greater than 90% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.