Thioredoxin/TRX 蛋白, Mouse

Thioredoxin/TRX proteins participate in multiple redox reactions, utilizing their reactive dithiol centers for reversible oxidation and disulfide bond formation.It catalyzes important dithiol-disulfide exchange and plays a key role in S-nitrosylation of cysteine residues in response to intracellular nitric oxide.Thioredoxin/TRX Protein, Mouse is the recombinant mouse-derived Thioredoxin/TRX protein, expressed by E.coli , with tag free.

硫氧还蛋白/TRX蛋白积极参与多种氧化还原反应，利用其活性中心二硫醇进行可逆氧化和二硫键形成，从而催化重要的二硫醇-二硫键交换反应。除了其经典的氧化还原功能外，硫氧还蛋白在靶蛋白内半胱氨酸残基的可逆 S-亚硝基化中发挥着至关重要的作用，有助于细胞对细胞内一氧化氮的反应。值得注意的是，它响应一氧化氮而亚硝基化 CASP3 的活性位点半胱氨酸，有效抑制 caspase-3 活性。此外，硫氧还蛋白在电离辐射细胞中表现出对 FOS/JUN AP-1 DNA 结合活性的调节影响，通过其氧化还原状态调节 AP-1 转录活性。此外，硫氧还蛋白还参与白细胞介素 2 受体 TAC (IL2R/P55) 表达的增强，强调了其在氧化还原调节之外的细胞过程中的多方面作用。

Measured by its ability to catalyze the reduction of insulin. The reaction leads to precipitation, which can be measured by absorbance at 650 nm. The specific activity is 9.72 A650/min/mg.

Mouse

E. coli

Tag Free

P10639 (M1-A105)

22166  [NCBI]

Full Length

Approximately 15 kDa,based on SDS-PAGE under reducing conditions.

Greater than 95% as determined by reducing SDS-PAGE

溶液.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.