TSLP 蛋白, Mouse (HEK293, Fc)

TSLP protein, as a cytokine, plays a key role in immune regulation. It induces monocytes to release T-cell attracting chemokines and significantly promotes the maturation of CD11c(+) dendritic cells. TSLP Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived TSLP protein, expressed by HEK293 , with C-hFc labeled tag. The total length of TSLP Protein, Mouse (HEK293, Fc) is 121 a.a., with molecular weight of 42-58 kDa.

TSLP（胸腺基质淋巴细胞生成素）蛋白是一种具有多种免疫调节功能的细胞因子。它诱导单核细胞释放吸引 T 细胞的趋化因子，并促进 CD11c(+) 树突状细胞的成熟，在免疫反应的调节中发挥着至关重要的作用。众所周知，TSLP 通过直接激活肥大细胞来影响过敏性炎症，从而促进复杂的过敏反应网络。TSLP通过与CRLF2和IL7R组成的受体复合物相互作用发挥作用，TSLP与CRLF2/TSLPR的结合是招募IL7R形成高亲和力三元复合物的机制先决条件。这些相互作用凸显了 TSLP 影响免疫细胞行为的复杂分子机制，强调了其在免疫系统调节和过敏反应中的作用。

Immobilized Mouse TSLP at 0.5 μg/mL (100 μL/well) can bind Monoclonal Anti-Human TSLP Antibody. The ED₅₀ of TSLP protein is 3.789 μg/mL, corresponding to a specific activity is 2.64×10⁵ units/mg.

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  Immobilized Mouse TSLP at 0.5 μg/mL (100 μL/well) can bind Monoclonal Anti-Human TSLP Antibody. The ED₅₀ of TSLP protein is 3.789 μg/mL, corresponding to a specific activity is 2.64×10⁵ units/mg.

Mouse

HEK293

C-hFc

Q9JIE6 (Y20-E140)

53603  [NCBI]

YNFSNCNFTSITKIYCNIIFHDLTGDLKGAKFEQIEDCESKPACLLKIEYYTLNPIPGCPSLPDKTFARRTREALNDHCPGYPETERNDGTQEMAQEVQNICLNQTSQILRLWYSFMQSPE

42-58 kDa

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  Greater than 95% as determined by reducing SDS-PAGE.

无菌粉末.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.