1. 重组蛋白
  2. Cytokines and Growth Factors
  3. VEGF & VEGFR
  4. VEGF
  5. VEGF-A
  6. VEGF164 蛋白, Mouse

VEGF164 蛋白, Mouse

目录号: HY-P7312
COA 产品使用指南

VEGF164 蛋白, Mouse是一个有效的血管生成调节剂,并能与信号蛋白受体neuropilin1 结合。

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规格 价格 是否有货 数量
10 μg ¥2200 In-stock
50 μg ¥6200 In-stock
100 μg   询价  

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  • 产品资料

  • 参考文献

描述

VEGF164 Protein, Mouse is a potent mediator of angiogenesis and binds the semaphorin receptor, neuropilin1.

研究背景

VEGF164被发现在诱导炎症方面更有效。体内阻断 VEGF 受体 (VEGFR)-1 显着抑制 VEGF164 诱导的角膜炎症。在体外,VEGF164 更有效地刺激内皮细胞上的细胞内粘附分子 (ICAM)-1 表达,这是由 VEGFR2 介导的效应。VEGF164 在诱导单核细胞趋化性方面也更有效,这是由 VEGFR1 介导的效应。在永生化人类白细胞系中,我们发现 VEGF164 可以更有效地诱导 VEGFR1 酪氨酸磷酸化[1]。VEGF164 是早期糖尿病视网膜病变发病机制中的重要亚型[2]

生物活性

The ED50 is <5 ng/mL as measured by human umbilical vein endothelial cells(HUVEC), corresponding to a specific activity of >2.0 × 105 units/mg.

种属

Mouse

表达系统

E. coli

标签

Tag Free

蛋白编号

Q00731-2 (A27-R190)

基因 ID

22339  [NCBI]

蛋白结构
N-term
VEGF164 (A27-R190)
Accession # Q00731-2
C-term
中文名
重组小鼠血管内皮生长因子164
同用名
VEGF-AA; rMuVEGF164; VPF
氨基酸序列

MAPTTEGEQKSHEVIKFMDVYQRSYCRPIETLVDIFQEYPDEIEYIFKPSCVPLMRCAGCCNDEALECVPTSESNITMQIMRIKPHQSQHIGEMSFLQHSRCECRPKKDRTKPEKHCEPCSERRKHLFVQDPQTCKCSCKNTDSRCKARQLELNERTCRCDKPRR

分子量

Approximately 38.8 kDa (Disulfide-linked homodimer)

纯度

Greater than 95% as determined by reducing SDS-PAGE.

性状

无菌粉末.

组分

Lyophilized after extensive dialysis against PBS, pH 7.4.

内毒素含量

<1 EU/μg, determined by LAL method.

复溶方法

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

保存条件 & 期限

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

文件资料
参考文献

VEGF164 Protein, Mouse 相关分类

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • 复溶计算器

  • 重组蛋白稀释计算器

  • 比活力计算器

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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