2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. iGluR Sodium Channel
  4. Remacemide hydrochloride

Remacemide hydrochloride  (Synonyms: 盐酸瑞马酰胺; FPL 12924AA)

目录号: HY-107695
产品使用指南

摩尔计算器

Remacemide hydrochloride (FPL 12924AA) 是一种钠离子通道的中等强度抑制剂，是 N-methyl-D-aspartate (NMDA) 受体 的弱无竞争力拮抗剂，对于 MK-801 结合的 IC50 值为 68 μM，对于 NMDA 电流的 IC50 值为 76 μM。Remacemide hydrochloride 是一种抗惊厥剂。

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Remacemide hydrochloride Chemical Structure

Remacemide hydrochloride Chemical Structure

CAS No. : 111686-79-4

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Remacemide hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Remacemide hydrochloride (FPL 12924AA), a moderate inhibitor of the Na+ channel, is a weak uncompetitive NMDA receptor antagonist with IC50s of 68 μM and 76 μM for MK-801 binding and NMDA currents, respectively[1]. Remacemide hydrochloride is an anticonvulsant agent[2].

IC50 & Target

IC50: 68-76 μM (NMDA receptor)[1]
IC50:160.6 μM(sodium channel)[2]
体外研究
(In Vitro)

Remacemide (hydrochloride) (0-1000 μM) blocks voltage-gated Na+ channels in rat cortical synaptosomes in a concentration-dependent manner,with an IC50 value of 160.6 μM[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Remacemide hydrochloride 相关抗体:
体内研究
(In Vivo)

Treatment with low- and high-dose Remacemide (100 mg/kg and 150 mg/kg) delays the acquisition of audio/visual discrimination (AVD) task performance in female Sprague-Dawley rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Sprague–Dawley rats ( 190-210 g )[3]
Dosage: 100 mg/kg and 150 mg/kg
Administration: Orogastric gavage; once a day; 7 days
Result: Increased the number of sessions required to complete audio/visual discrimination (AVD) training.
分子量

304.81

Formula

C17H21ClN2O
CAS 号
中文名称

盐酸瑞马酰胺；盐酸瑞马西胺；盐酸立马醋胺
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Remacemide hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Remacemide111686-79-4FPL 12924AA盐酸瑞马酰胺盐酸瑞马西胺盐酸立马醋胺iGluRSodium ChannelIonotropic glutamate receptorsNa channelsNa+ channelsanticonvulsantNMDAsodiumchannelInhibitorinhibitorinhibit

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