1. Alkaloids
  2. Retrorsine

Retrorsine 

目录号: HY-N6638
产品使用指南

Retrorsine 是一种天然存在的有毒吡咯利西啶生物碱。Retrorsine 可以与 DNA 结合,抑制肝细胞的增殖能力。

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Retrorsine Chemical Structure

Retrorsine Chemical Structure

CAS No. : 480-54-6

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Description

Retrorsine is a naturally occurring toxic pyrrolizidine alkaloid. Retrorsine can bind with DNA and inhibits the proliferative capacity of hepatocytes[1][2].

In Vitro

Retrorsine (60-240 μM; 24 hours) significantly reduces HSEC-CYP3A4 cells viability, depletes GSH, and increases formation of pyrrole-protein adducts[3].

Cell Viability Assay[3]

Cell Line: HSEC-CYP3A4 cells
Concentration: 60 μM, 120 μM , 240 μM
Incubation Time: 24 hours
Result: Significantly decreased cell viability.
In Vivo

Retrorsine (30 mg/kg; i.p.; twice) impairs liver regeneration in the PBL model not only by an S or G2/M phase block, but also by a block located before the G1/S transition of the cell cycle[1].

Animal Model: Male Wistar rats (180±20 g), portal branch ligation (PBL) model[1]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection, twice, separated by 2-week interval
Result: Strongly impaired the liver weight gain, protein and DNA synthesis as well as induction of cell cycle related proteins in the regenerating lobes after PBL.
Molecular Weight

351.39

Formula

C₁₈H₂₅NO₆

CAS No.

480-54-6

中文名称

倒千里光碱

SMILES

O=C(O[C@]1([H])CCN2[C@]1([H])C(COC([C@](CO)(O)[C@H](C)C/3)=O)=CC2)C3=C/C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vivo:
  • 1.

    HCl (pH 2.5) followed by neutralization by NaOH 0.1 N[1]

References
  • 摩尔计算器

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

RetrorsineOthershepatotoxicpyrrolizidinealkaloidPAInhibitorinhibitorinhibit

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产品名称:
Retrorsine
目录号:
HY-N6638
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