1. Immunology/Inflammation
  2. Interleukin Related
  3. Rilonacept

Rilonacept  (Synonyms: Arcalyst; IL 1 Trap; Interleukin 1 Trap)

目录号: HY-108822

Rilonacept (Arcalyst) 是一种二聚体融合蛋白,是一种白细胞介素 1 抑制剂。 Rilonacept 由连接到人 IgG1 的 Fc 部分的 IL-1R 组分的细胞外部分的配体结合域组成。 Rilonacept 可用于 cryopyrin 相关周期性综合征的研究。

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Rilonacept Chemical Structure

Rilonacept Chemical Structure

CAS No. : 501081-76-1

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Rilonacept (Arcalyst), a dimeric fusion protein, is a interleukin 1 inhibitor. Rilonacept consists of the ligand-binding domains of the extracellular portions of the IL-1R components linked to the Fc portion of human IgG1. Rilonacept can be used for the research of cryopyrin-associated periodic syndromes[1].

种属

Human

IC50 & Target[1]

IL-1

 

体外研究
(In Vitro)

Rilonacept blocks IL-1α signaling by acting as a soluble decoy receptor that binds IL-1β and prevents its interaction with cell–surface receptors, thereby reducing the inflammatory process[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS 号
性状

固体

颜色

White to off-white

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Rilonacept
目录号:
HY-108822
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