2. Anti-infection Epigenetics
  3. SARS-CoV Histone Methyltransferase DNA Methyltransferase
  4. SARS-CoV-2 nsp14-IN-1

SARS-CoV-2 nsp14-IN-1 (Compound 3) 是SARS-CoV-2 Nsp14 MTase 的典型的双底物抑制剂，其活性IC50 值为 0.061 μM。SARS-CoV-2 nsp14-IN-1 (Compound 3) 对人类甲基转移酶具有良好的选择性，可拮抗组蛋白赖氨酸、蛋白精氨酸、DNA 和 RNA 等 10 种人甲基转移酶。

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SARS-CoV-2 nsp14-IN-1 Chemical Structure

SARS-CoV-2 nsp14-IN-1 Chemical Structure

CAS No. : 2816165-02-1

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SARS-CoV-2 nsp14-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Histone Methyltransferase 亚型特异性产品:

查看所有亚型
EZH1 EZH2 DOT1L SMYD2 SMYD3 SUV39H2/KMT1B EHMT2/G9a/KMT1C EHMT1/GLP/KMT1D SETDB1/KMT2G SETD2/KMT3A SETD7/KMT7 SETD8/KMT5A PRMT1 PRMT3 PRMT4 PRMT5 PRMT6 PRMT7 PRMT8

查看 DNA Methyltransferase 亚型特异性产品:

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DNA Methyltransferase DNMT1 DNMT3 MGMT

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SARS-CoV-2 nsp14-IN-1 (Compound 3) is a prototypic bisubstrate inhibitor of SARS-CoV-2 Nsp14 MTase with an IC50 value of 0.061 μM. SARS-CoV-2 nsp14-IN-1 (Compound 3) has an excellent selectivity profile over a panel of human methyltransferases, can against apanel of 10 human MTases including histone lysine, proteinarginine, and DNA and RNA MTases[1].

IC50 & Target

IC50：0.061 μM (Nsp14 MTase) [1]
体外研究
(In Vitro)

SARS-CoV-2 nsp14-IN-1 (Compound 3) displays an excellent selectivity profile for Nsp14 MTase With an IC50 value of 0.061 μM.
SARS-CoV-2 nsp14-IN-1 (Compound 3) shows low passive diffusion rates in PAMPA.
SARS-CoV-2 nsp14-IN-1 (Compound 3) does not suffer major metabolic liabilities in human plasma and liver S9 fractions[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SARS-CoV-2 nsp14-IN-1 相关抗体:
分子量

456.48

Formula

C20H20N6O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SARS-CoV-2 nsp14-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SARS-CoV-2 nsp14-IN-12816165-02-1 SARS-CoVHistone MethyltransferaseDNA MethyltransferaseSARS coronavirusDNMTsDNA MTasesSARS-CoV-2Nsp14bisubstrate inhibitormethyltransferase inhibitorantiviralInhibitorinhibitorinhibit

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