1. Screening Libraries
  2. JAK/STAT Compound Library

JAK/STAT 化合物库 - JAK/STAT Compound Library

Cat. No.: HY-L008
Library Contents: XLSX PDF SDF

JAK/STAT 信号通路是细胞因子受体信号转导的核心,细胞因子受体是由 30 多种跨膜蛋白组成的超家族,可以识别特定的细胞因子,在血液形成和免疫应答中起关键作用。典型的 JAK/STAT 信号通路始于细胞因子及其相应的跨膜受体的结合。活化的 JAKs 随后磷酸化 STAT 单体,导致其二聚化、核易位和 DNA 结合。在哺乳动物中,有 4 种 JAK (JAK1, JAK2, JAK3, TYK2) 和 7 种 STATs (STAT1, STAT2, STAT3, STAT4, STAT5a, STAT5b, STAT6)。由于 JAK/STAT 通路在细胞凋亡、炎症等过程中起着重要作用,因此该信号通路的功能失调可能导致多种疾病的发生。如,JAK/STAT信号的改变可能导致癌症和免疫系统疾病,如严重综合型免疫缺乏症 (SCID)。

MCE 提供 196 种 JAK/STAT 信号通路相关产品,可以用于 JAK/STAT 信号通路研究及相关疾病研究。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
Size (Pre-dissolved Solution or Solid) Price Stock
30 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

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50 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

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100 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

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2 × 100 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

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sales@MedChemExpress.cn

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  • Description

  • Product Details

  • Composition

  • Documentation

Description
& Advantages

•   A unique collection of 196 bioactive compounds related to JAK/STAT signaling used for high throughput screening (HTS) and high content screening (HCS).

•   Targets include JAK, STAT, EGFR, Pim, etc.

•   A useful tool for JAK/STAT-related drug discovery.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   More detailed compound information with structure, IC50, and brief introduction.

•   NMR and HPLC validated to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

Product Details
Formulation:
A collection of 196 JAK/STAT related compounds supplied as pre-dissolved DMSO solutions or Solid .
Solution: 194 compounds supplied in 10 mM solution, 2 compounds supplied in 2 mM solution.
Container:
96 Well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
-80°C
Shipping:
Blue ice
Composition

JAK/STAT Compound Library

Source: MedChem Express

Contents of JAK/STAT Compound Library
Documentation

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    产品名称:
    JAK/STAT Compound Library
    目录号:
    HY-L008
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack