2. Neuronal Signaling
  3. Amyloid-β
  4. Semax acetate

Semax acetate 是一种能透过血脑屏障的促肾上腺皮质激素样肽，可与铜离子 (Cu2+) 形成稳定的复合物。Semax acetate 是 Adrenocorticotropic Hormone (ACTH) (4-10) 的合成肽类似物。Semax acetate 具有免疫调节、促智和神经保护的活性。Semax acetate 可用于阿尔兹海默症、脑缺血等中枢神经系统疾病的研究。

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Custom Peptide Synthesis

Semax acetate Chemical Structure

Semax acetate Chemical Structure

CAS No. : 2828433-33-4

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规格 价格 是否有货 数量
1 mg ￥350
In-stock
5 mg ￥630
In-stock
10 mg ￥990
In-stock
25 mg ￥1800
In-stock
50 mg ￥2700
In-stock
100 mg ￥3870
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

Other Forms of Semax acetate:

Semax acetate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Semax acetate is a BBB-penetrable adrenocorticotropic hormone-like peptide and can form stable complexes with Cu2+. Semax acetate is a synthetic peptide analog of Adrenocorticotropic hormone (ACTH) (4-10). Semax acetate has immunomodulatory, nootropic and neuroprotective activities. Semax acetate can be used in the research of central nervous system diseases such as Alzheimer's disease and cerebral ischemia[1][2][3][4][5].

体外研究
(In Vitro)

Semax (25-100 μM, 48 h) acetate 可降低 Aβ 寡聚体的水平[1]。
Semax (100 nM) acetate 可提高基底前脑胆碱能神经元的存活率，并刺激离体基底前脑组织培养物中胆碱乙酰转移酶的活性[2]。
Semax (10 μM, 0-24 h) acetate 在新生大鼠基底前脑来源的神经胶质细胞中，可提高 BDNF 和 NGF 水平[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Semax acetate 相关抗体:

Real Time qPCR[3]

Cell Line: Glial cell cultures from rat basal forebrain
Concentration: 10 μM
Incubation Time: 0.5, 1, 2, 3, 4, 8, 16 and 24 h
Result: Increased the mRNA levels of BDNF and NGF.
体内研究
(In Vivo)

Semax (100 μg/kg; 腹腔注射; 单剂量) acetate 在大鼠局灶性脑缺血模型中具有改善作用[4]。
Semax (0.15 mg/kg; 腹腔注射; 单剂量) acetate 可增加小鼠下丘脑和纹状体中 5-HIAA 的浓度[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Ischemia (pMCAO) rats[4]
Dosage: 100 μg/kg
Administration: Intraperitoneal injections (i.p.), performed 15 min, 1, 4 and 8 h after permanent middle cerebral artery occlusion (pMCAO).
Result: Affected the expression of genes related to the immune system. At 3 hours after pMCAO, it influenced the expression of genes regulating the activity of immune cells such as macrophages, neutrophils, and lymphocytes. At 24 hours after pMCAO, the effect on the immune response was significantly increased, with over 50% of the genes with altered expression involved in the immune response.
Affected the expression of genes related to the vascular system. At 3 hours after pMCAO, it influenced genes involved in vasculogenesis, hematopoiesis, and endothelial cell migration. At 24 hours after pMCAO, it affected the development of endothelial tissue, the migration of smooth muscle cells, and the activation of blood cells.
分子量

873.97

Formula

C39H55N9O12S
CAS 号
性状

固体

颜色

White to off-white

Sequence

Met-Glu-His-Phe-Pro-Gly-Pro
Sequence Shortening

MEHFPGP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 150 mg/mL (171.63 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.1442 mL 5.7210 mL 11.4420 mL
5 mM 0.2288 mL 1.1442 mL 2.2884 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

Semax acetate 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1442 mL 5.7210 mL 11.4420 mL 28.6051 mL
5 mM 0.2288 mL 1.1442 mL 2.2884 mL 5.7210 mL
10 mM 0.1144 mL 0.5721 mL 1.1442 mL 2.8605 mL
15 mM 0.0763 mL 0.3814 mL 0.7628 mL 1.9070 mL
20 mM 0.0572 mL 0.2861 mL 0.5721 mL 1.4303 mL
25 mM 0.0458 mL 0.2288 mL 0.4577 mL 1.1442 mL
30 mM 0.0381 mL 0.1907 mL 0.3814 mL 0.9535 mL
40 mM 0.0286 mL 0.1430 mL 0.2861 mL 0.7151 mL
50 mM 0.0229 mL 0.1144 mL 0.2288 mL 0.5721 mL
60 mM 0.0191 mL 0.0954 mL 0.1907 mL 0.4768 mL
80 mM 0.0143 mL 0.0715 mL 0.1430 mL 0.3576 mL
100 mM 0.0114 mL 0.0572 mL 0.1144 mL 0.2861 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Semax2828433-33-4Amyloid-ββ-amyloid peptideAβAbetaIschemiaBDNFastrocytesnootropicneuroprotectiveischemia? modelAD modelneuronsInhibitorinhibitorinhibit

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