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    Membrane Transporter/Ion Channel
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    P-glycoprotein
  3. Sinapine hydroxide

Sinapine hydroxide 

目录号: HY-N5077B
产品使用指南

Sinapine hydroxide 是一种从十字花科物种的种子中分离出来的生物碱。Sinapine hydroxide 具有抗炎,抗氧化,抗肿瘤,抗血管生成和放射防护作用。Sinapine hydroxide 还是一种乙酰胆碱酯酶 (AChE) 抑制剂,可用于研究阿尔茨海默症,共济失调,重症肌无力和帕金森氏病。

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Sinapine hydroxide Chemical Structure

Sinapine hydroxide Chemical Structure

CAS No. : 122-30-5

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Description

Sinapine hydroxide is an alkaloid isolated from seeds of the cruciferous species. Sinapine hydroxide exhibits anti-inflammatory, anti-oxidant, anti-tumor, anti-angiogenic and radio-protective effects. Sinapine hydroxide is also an acetylcholinesterase (AChE) inhibitor and can be used for the research of Alzheimer’s disease, ataxia, myasthenia gravis, and Parkinson’s disease[1][2][3][4].

IC50 & Target

AChE[4], P-gp[1]

In Vitro

Sinapine (6 or 60 μM; 1 h) counteracts H2O2 and antimycin A-induced mitochondrial oxidative stress in cardiomyocytes[1].
Sinapine (10-200 μM; 24 h) inhibits the proliferation of Caco-2 cells in a dose-dependent manner, and has relatively low toxicity[3].
Sinapine (10-200 μM; 24 h) promotes doxorubicin accumulation in Caco-2 cell by inducing P-glycoprotein (P-gp) decrease[3].
Sinapine (10-200 μM; 24 h) significantly reduces phosphorylation of FRS2α, ERK1/2[3].

In Vivo

Sinapine reduces non-alcoholic fatty liver disease in mice by modulating the composition of the gut microbiota[2].

Molecular Weight

327.37

Formula

C₁₆H₂₅NO₆

CAS No.

122-30-5

SMILES

O=C(OCC[N+](C)(C)C)/C=C/C(C=C1OC)=CC(OC)=C1O.[OH-]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

SinapineAChEP-glycoproteinAcetylcholinesteraseP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243cruciferousanti-inflammatoryanti-oxidantanti-tumoranti-angiogenicradio-protectiveacetylcholinesteraseAlzheimer’sdiseaseataxiamyastheniagravisParkinson’sInhibitorinhibitorinhibit

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Sinapine hydroxide
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HY-N5077B
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