1. Epigenetics
    Anti-infection
  2. Histone Methyltransferase
    Fungal
    Antibiotic
  3. Sinefungin

Sinefungin (Synonyms: Adenosyl-Ornithine; A-9145; Antibiotic 32232RP)

目录号: HY-101938 纯度: ≥99.0%
产品使用指南

Sinefungin是病毒粒子mRNA (鸟嘌呤-7-)-甲基转移酶、 mRNA (核苷-2'-)-甲基转移酶和病毒增殖的有效抑制剂。Sinefungin 是一种 SET7/9 抑制剂,通过抑制H3K4甲基化来改善肾纤维化。

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Sinefungin Chemical Structure

Sinefungin Chemical Structure

CAS No. : 58944-73-3

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规格 价格 是否有货 数量
1 mg ¥3000 In-stock
5 mg   询价  
10 mg   询价  

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sinefungin is a potent inhibitor of virion mRNA(guanine-7-)-methyltransferase, mRNA(nucleoside-2'-)-methyltransferase, and viral multiplication[1]. Sinefungin, a SET7/9 inhibitor, ameliorates renal fibrosis by inhibiting H3K4 methylation[2].

体外研究
(In Vitro)

Sinefungin (0.5 or 1.0 μg/mL, 60 minutes) ameliorates the TGF-β1-induced increase of α-SMA and inhibits the upregulation of histone H3K4 monomethylation in renal epithelial cells and renal fibroblast cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: Renal epithelial cells.
Concentration: 0.5 or 1.0 μg/mL.
Incubation Time: Pretreatment 60 minutes before TGF-β1 (10 ng/mL).
Result: Significantly reduced TGF-β1-inducedα-SMA protein expression and inhibited H3K4me1 in a dose-dependent manner in both NRK-52E and NRK-49F cells.
体内研究
(In Vivo)

Sinefungin (10 mg/kg, per day immediately after UUO) ameliorates renal fibrosis in obstructive nephropathy[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (8 weeks of age)[2].
Dosage: 10 mg/kg
Administration: Administered intraperitoneally per day immediately after UUO (prepared as a suspension in distilled water and 0.9% NaCl solution).
Result: Inhibited α-SMA protein expression.
Ameliorated those (α-SMA, FSP-1, collagen 1, collagen 3) both at 3 and 7 days after UUO.
分子量

381.39

Formula

C₁₅H₂₃N₇O₅

CAS 号
SMILES

O[C@H]([C@@H]1O)[C@@H](O[C@@H]1C[C@@H](N)CC[C@H](N)C(O)=O)N2C(N=CN=C3N)=C3N=C2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

H2O : 100 mg/mL (262.20 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6220 mL 13.1099 mL 26.2199 mL
5 mM 0.5244 mL 2.6220 mL 5.2440 mL
10 mM 0.2622 mL 1.3110 mL 2.6220 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献

Purity: ≥99.0%

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

Keywords:

SinefunginAdenosyl-Ornithine A-9145 Antibiotic 32232RPA9145A 9145A-9145Histone MethyltransferaseFungalAntibioticUUPα-SMAFSP-1collagen 1collagen 3H3K4Inhibitorinhibitorinhibit

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Sinefungin
目录号:
HY-101938
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