2. Membrane Transporter/Ion Channel
  3. Sodium Channel
  4. SLC13A5-IN-1

SLC13A5-IN-1 是一种选择性柠檬酸钠协同转运蛋白 (SLC13A5) 抑制剂。SLC13A5-IN-1 完全阻断 HepG2 细胞摄取 14C-柠檬酸，IC50 值为 0.022 μM。SLC13A5-IN-1 可以用于研究代谢和/或心血管疾病的研究。SLC13A5-IN-1 源于专利 WO2018104220A1，化合物 I-5。

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SLC13A5-IN-1 Chemical Structure

SLC13A5-IN-1 Chemical Structure

CAS No. : 2227548-95-8

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规格 价格 是否有货 数量
5 mg ￥1125
In-stock
10 mg ￥1800
In-stock
25 mg ￥3375
In-stock
50 mg ￥5400
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Customer Review

SLC13A5-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SLC13A5-IN-1 is a selective sodium-citrate co-transporter (SLC13A5) inhibitor. SLC13A5-IN-1 completely blocks the uptake of 14C-citrate with an IC50 value of 0.022 μM in HepG2 cells. SLC13A5-IN-1 has the potential for the treatment of metabolic and/or cardiovascular diseases. SLC13A5-IN-1 is extracted from patent WO2018104220A1, Compound I-5[1].

IC50 & Target

IC50: 0.022 μM (HepG2/14C-Citrate Uptake Assay); 0.056 μM (recombinant hSLC3A5/14C-Citrate Uptake Assay)[1]
体外研究
(In Vitro)

SLC13A5-IN-1 exhibits an IC50 of 0.022 μM in HepG2/14C-Citrate Uptake Assay. HepG2 cells endogenously express hSLC13A5 transporter which is responsible for the uptake of citrate into these cells. Uptake of 14C-citrate can be completely blocked by SLC13A5-IN-1 and the signal can be competed with unlabelled citrate. T[1].
SLC13A5-IN-1 exhibits an IC50 of 0.056 μM in recombinant hSLC3A5/14C-Citrate Uptake Assay[1].
SLC13A5-IN-1 exhibits an IC50 of 100 μM in recombinant Human GlyT2/3H-Glycine Uptake Assay. The human embryonic kidney 293 cells are used that stably over-express the human GlyT2 receptor which is responsible for the uptake of glycine into these cells. Uptake of 3H-glycine can be completely blocked by SLC13A5-IN-1[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SLC13A5-IN-1 相关抗体:
分子量

461.79

Formula

C19H19Cl3N2O3S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 12.5 mg/mL (27.07 mM; 超声助溶 (<60°C); 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.1655 mL 10.8274 mL 21.6549 mL
5 mM 0.4331 mL 2.1655 mL 4.3310 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
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体积
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分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

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体积 (start)

V1

=
浓度 (final)

C2

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体积 (final)

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动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

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每只动物的给药体积

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动物数量

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由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

SLC13A5-IN-1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1655 mL 10.8274 mL 21.6549 mL 54.1372 mL
5 mM 0.4331 mL 2.1655 mL 4.3310 mL 10.8274 mL
10 mM 0.2165 mL 1.0827 mL 2.1655 mL 5.4137 mL
15 mM 0.1444 mL 0.7218 mL 1.4437 mL 3.6091 mL
20 mM 0.1083 mL 0.5414 mL 1.0827 mL 2.7069 mL
25 mM 0.0866 mL 0.4331 mL 0.8662 mL 2.1655 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SLC13A5-IN-12227548-95-8Sodium ChannelNa channelsNa+ channelsCitrateUptakemetaboliccardiovasculardiseaseSLC13A5hSLC3A5Inhibitorinhibitorinhibit

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