1. Protein Tyrosine Kinase/RTK
    Stem Cell/Wnt
    Metabolic Enzyme/Protease
  2. PKA
    Phosphodiesterase (PDE)
  3. Sp-cAMPS

Sp-cAMPS 

目录号: HY-100530B
产品使用指南

Sp-cAMPS,一种 cAMP 类似物,是一种依赖 cAMP 的 PKA IPKA II 的有效激活剂。Sp-cAMPS 还是一种有效的竞争性磷酸二酯酶 (PDE3A) 抑制剂,Ki 为 47.6 µM。Sp-cAMPS 以 EC50 为 40 μM 来结合 PDE10 GAF 域。

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Sp-cAMPS Chemical Structure

Sp-cAMPS Chemical Structure

CAS No. : 71774-13-5

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Description

Sp-cAMPS, a cAMP analog, is potent activator of cAMP-dependent PKA IPKA II. Sp-cAMPS is also a potent, competitive phosphodiesterase (PDE3A) inhibitor with a Ki of 47.6 µM. Sp-cAMPS binds the PDE10 GAF domain with an EC50 of 40 μM[1][2][3].

IC50 & Target[2][3]

PKA I

 

PKA II

 

PDE3A

47.6 μM (Ki)

PDE10 GAF domain

50 μM (EC50)

In Vitro

Treatment of hepatocytes with Sp-cAMPS, the stimulatory diastereomer of adenosine cyclic 3',5'-phosphorothioate, mimics the response seen with glucagon. The glucagon-stimulated increases in the level of Ca2+ can be mimicked by Sp-cAMPS[4].

In Vivo

In chronic alcohol consumption (CAC) mice, direct infusion of the Sp-cAMPS (1 µg/µL) into the prefrontal cortex significantly improves or impairs, respectively, working memory performance in withdrawn and water animals[5].

Molecular Weight

345.27

Formula

C₁₀H₁₂N₅O₅PS

CAS No.

71774-13-5

SMILES

O[C@H]1[C@@H](O[C@@]2([H])[C@@]1([H])O[P@](OC2)(S)=O)N3C4=C(C(N)=NC=N4)N=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Sp-cAMPSPKAPhosphodiesterase (PDE)Protein kinase APDE3AcAMPPKA IPKA IIPDE10Ca2+glucagonmemoryInhibitorinhibitorinhibit

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产品名称:
Sp-cAMPS
目录号:
HY-100530B
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