2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Epigenetics Cell Cycle/DNA Damage Apoptosis
  3. STING IKK Reactive Oxygen Species (ROS) IFNAR PARP Caspase
  4. STING-IN-17

STING-IN-17 是一种口服活性的 STING (人源 STING IC50 = 29 nM, 鼠源 STING IC50 = 15 nM) 抑制剂。STING-IN-17 可以抑制 STING、TBK1、IRF3 的磷酸化。STING-IN-17 剂量依赖性抑制 IP10、IFNB1、ISG56 mRNA 表达。STING-IN-17 可以减少 ROS 并抑制 cleaved-PARP/caspase-3 表达。STING-IN-17 可以改善肾功能。STING-IN-17 可以用于急性肾损伤等炎症性疾病的研究。

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STING-IN-17

STING-IN-17 Chemical Structure

CAS No. : 3069635-58-8

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STING-IN-17 相关抗体

Top Publications Citing Use of Products

查看 IKK 亚型特异性产品:

查看所有亚型
IKK-α IKK-β IKK IKKε TBK1

查看 PARP 亚型特异性产品:

查看所有亚型
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

查看 Caspase 亚型特异性产品:

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

STING-IN-17 is an orally active STING (human STING IC50 = 29 nM, mouse STING IC50 = 15 nM) inhibitor. STING-IN-17 can inhibit the phosphorylation of STING, TBK1 and IRF3. STING-IN-17 dose dependently inhibits the mRNA expression of IP10, IFNB1 and ISG56. STING-IN-17 can reduce ROS and inhibit the expression of cleaved-PARP/caspase-3. STING-IN-17 can improve kidney function. STING-IN-17 can be used for research on inflammatory conditions such as acute kidney injury[1].

IC50 & Target[1]

TBK1

 

Caspase 3

 

分子量

550.55

Formula

C30H26F4N4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

STING-IN-17 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

STING-IN-173069635-58-8STINGIKKReactive Oxygen Species (ROS)IFNARPARPCaspaseStimulator of Interferon GenesTMEM173MITAERISMPYSIκB kinaseI kappa B kinase Interferon-α/β receptorInterferon-alpha/beta receptor poly ADP ribose polymeraseTBK1IRF3IP10IFNB1ISG56ROScleaved-PARPcaspase-3acute kidney injuryInhibitorinhibitorinhibit

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