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  3. Sulfadoxine-d3

Sulfadoxine-d3  (Synonyms: 磺胺多辛-d3; Sulphadoxine d3)

目录号: HY-B0439S1 纯度: ≥98.0%
COA 产品使用指南

Sulfadoxine-d3Sulfadoxine (HY-B0439) 的氘代物。Sulfadoxine 是一种磺酰胺类化合物,通常与 Pyrimethamine (HY-18062) 联合用于耐多药恶性疟原虫和间日疟原虫的防治。但与 Pyrimethamine 不同,Sulfadoxine 对 HIV 的复制和 MT-2 细胞周期进展没有影响。Sulfadoxine 还能抑制呼吸道、泌尿道感染。

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Sulfadoxine-d<sub>3</sub> Chemical Structure

Sulfadoxine-d3 Chemical Structure

CAS No. : 1262770-70-6

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sulfadoxine-d3 is a deuterium labeled Sulfadoxine (HY-B0439). Sulfadoxine is a sulfonamide that is used, usually in combination with Pyrimethamine (HY-18062), for multidrug-resistant Plasmodium falciparum and P. vivax inhibition. Unlike PYR, Sulfadoxine has no impact on HIV replication or MT-2 cell cycle progression. But also Sulfadoxine exhibits suppression on respiratory, and urinary tract infections[1][2][3][4].

IC50 & Target

Plasmodium

 

体外研究
(In Vitro)

磺胺多辛 (0-100 μM;7 d) 对 MT-2 细胞中 HIV-1 的复制无影响[4].
磺胺多辛 (100 μM;48 h) 对 MT-2 细胞 S 期积累的诱导无影响[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

磺胺多辛 (0.1, 0.3, 10 mg/kg/d; 口服; 每日1次, 连用 3天) 与阿奇霉素 (30 mg/kg/d; 口服; 每日1次, 连用 3天),能够抑制小鼠疟疾模型中的血期寄生虫或约氏疟原虫子孢子[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

313.35

Formula

C12H11D3N4O4S

CAS 号
性状

固体

颜色

White to off-white

中文名称

磺胺多辛-d3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥98.0%

参考文献

Sulfadoxine-d3 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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HY-B0439S1
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