2. Membrane Transporter/Ion Channel Neuronal Signaling GPCR/G Protein
  3. Potassium Channel mAChR Calcium Channel
  4. Terodiline

Terodiline  (Synonyms: 特罗地林)

目录号: HY-16489
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摩尔计算器

Terodiline 是一种解痉剂，可阻断 hERG 电流，IC50 为 375 nM。Terodiline 具有抗胆碱能 (anticholinergic) 和钙拮抗剂 (calcium) 特性，可有效减少逼尿肌不稳定引起的异常膀胱收缩，可用于尿失禁的研究。

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Terodiline Chemical Structure

Terodiline Chemical Structure

CAS No. : 15793-40-5

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Terodiline 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Terodiline, an antispasmodic agent, blocks hERG current with the IC50 of 375 nM. Terodiline has both anticholinergic and calcium antagonist properties, and effectively reduces abnormal bladder contractions caused by detrusor instability. Terodiline can be used for the research of urinary incontinence[1][2].

IC50 & Target

mAChR[1]
Ca2+ channel[1]
体内研究
(In Vivo)

Terodiline (80 mg/kg; S.C.) is equipotent in inhibiting intravesical bladder pressure and carbachol-induced salivary secretion (ID50= 24 and 35 mg/kg, respectively), and in increasing pupil diameter (ED50=59 mg/kg)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fmale or male Hartley guinea pigs (200-600 g)[1]
Dosage: 80 mg/kg
Administration: Administered S.C.
Result: Yielded an ID50 of 24±6 mg/kg. Higher doses were Iethal.
分子量

281.44

Formula

C20H27N
CAS 号
中文名称

特罗地林
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Terodiline 相关分类

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Keywords:

Terodiline15793-40-5特罗地林Potassium ChannelmAChRCalcium ChannelKcsAMuscarinic acetylcholine receptorCa2+ channelsCa channelshERG currentanticholinergiccalcium antagonisturinary incontinenceInhibitorinhibitorinhibit

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