1. GPCR/G Protein
    Neuronal Signaling
    Membrane Transporter/Ion Channel
  2. mAChR
    Calcium Channel
  3. Terodiline hydrochloride

Terodiline hydrochloride 

目录号: HY-16489A
产品使用指南

Terodiline hydrochloride 是一种 M1 选择性的毒蕈碱受体 (muscarinic receptor; mAChR) 拮抗剂。 对兔输精管 (M1),心房 (M2),膀胱 (M3),回肠肌 (M3) 的 Kb 分别为 15,160,280,和 198 nM。Terodiline hydrochloride 还是钙通道 (Ca2+) 阻断剂。Terodiline hydrochloride 可用于治疗尿频和急迫性尿失禁。

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Terodiline hydrochloride Chemical Structure

Terodiline hydrochloride Chemical Structure

CAS No. : 7082-21-5

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Description

Terodiline hydrochloride is an M1-selective muscarinic receptor (mAChR) antagonist with Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline hydrochloride also is a Ca2+ blocker. Terodiline hydrochloride acts as a treatment for urinary frequency and urge incontinence[1].

IC50 & Target

mAChR[1]
Ca2+ channel[1]

In Vivo

Terodiline (80 mg/kg; S.C.) is equipotent in inhibiting intravesical bladder pressure and carbachol-induced salivary secretion (ID50= 24 and 35 mg/kg, respectively), and in increasing pupil diameter (ED50=59 mg/kg)[1].

Animal Model: Fmale or male Hartley guinea pigs (200-600 g)[1]
Dosage: 80 mg/kg
Administration: Administered S.C.
Result: Yielded an ID50 of 24±6 mg/kg. Higher doses were Iethal.
Molecular Weight

317.90

Formula

C₂₀H₂₈ClN

CAS No.

7082-21-5

SMILES

CC(NC(C)(C)C)CC(C1=CC=CC=C1)C2=CC=CC=C2.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

TerodilinemAChRCalcium ChannelMuscarinic acetylcholine receptorCa2+ channelsCa channelsmuscarinicreceptorCa2+blockerurinaryfrequencyurgeincontinenceantianginalInhibitorinhibitorinhibit

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产品名称:
Terodiline hydrochloride
目录号:
HY-16489A
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