2. GPCR/G Protein Neuronal Signaling Membrane Transporter/Ion Channel
  3. mAChR Calcium Channel
  4. Terodiline hydrochloride

Terodiline hydrochloride  (Synonyms: 盐酸特罗地林)

目录号: HY-16489A
COA 产品使用指南

摩尔计算器

Terodiline hydrochloride 是一种 M1 选择性的毒蕈碱受体 (muscarinic receptor; mAChR) 拮抗剂。 对兔输精管 (M1)，心房 (M2)，膀胱 (M3)，回肠肌 (M3) 的 Kb 分别为 15，160，280，和 198 nM。Terodiline hydrochloride 还是钙通道 (Ca2+) 阻断剂。Terodiline hydrochloride 可用于尿频和急迫性尿失禁的研究。

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Terodiline hydrochloride Chemical Structure

Terodiline hydrochloride Chemical Structure

CAS No. : 7082-21-5

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规格 价格 是否有货
1 mg ￥1350
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5 mg ￥3400
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Customer Review

Other Forms of Terodiline hydrochloride:

Terodiline hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Terodiline hydrochloride is an M1-selective muscarinic receptor (mAChR) antagonist with Kbs of 15, 160, 280, and 198 nM in rabbit vas deferens (M1), atria (M2), bladder (M3) and ileal muscle (M3), respectively. Terodiline hydrochloride also is a Ca2+ blocker. Terodiline hydrochloride acts as a treatment for urinary frequency and urge incontinence[1].

IC50 & Target

mAChR[1]
Ca2+ channel[1]
体内研究
(In Vivo)

Terodiline (80 mg/kg; S.C.) is equipotent in inhibiting intravesical bladder pressure and carbachol-induced salivary secretion (ID50= 24 and 35 mg/kg, respectively), and in increasing pupil diameter (ED50=59 mg/kg)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fmale or male Hartley guinea pigs (200-600 g)[1]
Dosage: 80 mg/kg
Administration: Administered S.C.
Result: Yielded an ID50 of 24±6 mg/kg. Higher doses were Iethal.
分子量

317.90

Formula

C20H28ClN
CAS 号
性状

固体

颜色

White to off-white

中文名称

盐酸特罗地林
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料
参考文献

Terodiline hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Terodiline7082-21-5盐酸特罗地林mAChRCalcium ChannelMuscarinic acetylcholine receptorCa2+ channelsCa channelsmuscarinicreceptorCa2+blockerurinaryfrequencyurgeincontinenceantianginalInhibitorinhibitorinhibit

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