1. Immunology/Inflammation
  2. Interleukin Related
  3. Tildrakizumab

Tildrakizumab  (Synonyms: SCH 900222; MK 3222; Anti-Human IL23 Recombinant Antibody)

目录号: HY-P99256 纯度: ≥95.0%
COA

Tildrakizumab (SCH 900222) 是一种人源化抗-IL-23 (p19 亚基) 单克隆抗体。IL-23 是维持 Th17 细胞表型的关键细胞因子。Tildrakizumab 对单链 IL-23 具有高亲和力 (Kd: 136 pM)。Tildrakizumab 对中度至重度斑块状银屑病有效。

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Tildrakizumab Chemical Structure

Tildrakizumab Chemical Structure

CAS No. : 1326244-10-3

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tildrakizumab (SCH 900222) is a humanized anti-IL-23 (p19 subunit) monoclonal antibody. IL-23 is a critical cytokine to maintain the Th17 cell phenotype. Tildrakizumab has high-affinity for single-chain IL-23 (Kd: 136 pM). Tildrakizumab is effective against moderate to severe plaque psoriasis[1][2][3].

IC50 & Target

IL-23[1]

体外研究
(In Vitro)

Tildrakizumab 抑制表达人 IL-23Rα 和 IL-12Rβ1 受体的 HeLa 细胞中 IL-23 诱导的 STAT3 信号,IC50 为 23 pM[2]
Tildrakizumab 通过负变构调节降低 IL-23 对 IL-23Rα 的亲和力[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Tildrakizumab (100 mg/kg,皮下注射,每 2 周一次,最多 9 个月) 在食蟹猴中具有良好的耐受性 (毒性研究)[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

144.4 (kDa)

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

纯度: ≥95.0%

参考文献

Tildrakizumab 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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