2. Immunology/Inflammation
  3. Toll-like Receptor (TLR)
  4. TLR2 antagonist-1

TLR2 antagonist-1 是一种选择性 Toll 样受体 2 (TLR2) 拮抗剂。TLR2 antagonist-1 能有效抑制 TLR2 的过度激活 (IC50 值为 11.41 μM) 以及炎症因子的产生。TLR2 antagonist-1 具有代谢稳定性，在小鼠肝微粒体中的半衰期 (T1/2) 为 16.67 分钟。TLR2 antagonist-1 可用于炎症、免疫学和神经系统疾病的研究。

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TLR2 antagonist-1

TLR2 antagonist-1 Chemical Structure

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TLR2 antagonist-1 相关抗体

Top Publications Citing Use of Products

查看 Toll-like Receptor (TLR) 亚型特异性产品:

查看所有亚型
TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TLR2 antagonist-1 is a selective Toll-like receptor 2 (TLR2) antagonist. TLR2 antagonist-1 can effectively inhibit excessive TLR2 activation (IC50 = 11.41 μM) and the production of inflammatory factors. TLR2 antagonist-1 has metabolic stability with a half-life (T1/2) of 16.67 min in mouse liver microsomes. TLR2 antagonist-1 can be used for the researches of inflammation, immunology, and neurological disease[1].

IC50 & Target[1]

TLR2

11.41 μM (IC50)

体外研究
(In Vitro)

TLR2 antagonist-1 (Compound T30) 的细胞毒性较低，在 RAW 264.7 细胞中的 CC50 值为 37.25 μM[1]。
TLR2 antagonist-1 (12.5-25 μM) 可抑制 HEK-Blue hTLR2 细胞中的 hTLR2/NF-κB 通路[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TLR2 antagonist-1 相关抗体:
分子量

391.78

Formula

C18H15ClFN3O4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TLR2 antagonist-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TLR2 antagonist-1Toll-like Receptor (TLR)Toll-like receptorTLR2InflammationImmunologyInhibitorinhibitorinhibit

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产品名称：
TLR2 antagonist-1
目录号：
HY-175533
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