2. Cell Cycle/DNA Damage Cytoskeleton Protein Tyrosine Kinase/RTK NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis
  3. Microtubule/Tubulin VEGFR Reactive Oxygen Species (ROS) Apoptosis
  4. Tubulin/VEGFR-2-IN-1

Tubulin/VEGFR-2-IN-1 是一种 tubulin 和 VEGFR 双重抑制剂 (IC50 = 1.52 μM)，具有抗血管生成活性。Tubulin/VEGFR-2-IN-1 对癌细胞表现出强效的细胞毒性。Tubulin/VEGFR-2-IN-1 提高 HepG-2 细胞中的 ROS 产生，诱导凋亡 (apoptosis) 并引起 G0/G1 期阻滞。Tubulin/VEGFR-2-IN-1 抑制 HepG-2 细胞的迁移能力和克隆形成能力。Tubulin/VEGFR-2-IN-1 可用于癌症研究。

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Tubulin/VEGFR-2-IN-1

Tubulin/VEGFR-2-IN-1 Chemical Structure

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Tubulin/VEGFR-2-IN-1 相关抗体

Top Publications Citing Use of Products

查看 VEGFR 亚型特异性产品:

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tubulin/VEGFR-2-IN-1 is a dual inhibitor of tubulin and VEGFR-2 (IC50 = 1.52 μM) with anti-angiogenic activity. Tubulin/VEGFR-2-IN-1 exhibits potent cytotoxicity against the cancer cells. Tubulin/VEGFR-2-IN-1 elevates ROS production, induces apoptosis and causes G0/G1 phase arrest in HepG-2 cells. Tubulin/VEGFR-2-IN-1 inhibits the migratory ability and the clonogenic ability in HepG-2 cells. Tubulin/VEGFR-2-IN-1 can be used for the study of cancer[1].

IC50 & Target[1]

VEGFR-2

1.52 μM (IC50)

体外研究
(In Vitro)

Tubulin/VEGFR-2-IN-1 (Compound 8u) (48 小时) 对多种癌细胞系表现出强效的细胞毒性，对 HepG-2、A549、MCF-7 和 HCT-116 细胞的 IC50 值分别为 1.88 μM、14.76 μM、16.47 μM 和 15.47 μM[1]。
Tubulin/VEGFR-2-IN-1 (0.94-3.76 μM，48 小时) 提高 HepG-2 细胞中的 ROS 产生，诱导凋亡并引起 G0/G1 期阻滞[1]。
Tubulin/VEGFR-2-IN-1 (0.94-3.76 μM，48 小时) 抑制 HepG-2 细胞的迁移能力和克隆形成能力[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tubulin/VEGFR-2-IN-1 相关抗体:

Apoptosis Analysis[1]

Cell Line: HepG-2 cells
Concentration: 0.94, 1.88, 3.76 μM
Incubation Time: 48 h
Result: Showed a concentration-dependent increase in apoptotic cell populations.

Cell Cycle Analysis[1]

Cell Line: HepG-2 cells
Concentration: 0.94, 1.88, 3.76 μM
Incubation Time: 48 h
Result: Caused G0/G1 phase arrest in HepG-2 cells in a dose-dependent manner.

Cell Migration Assay [1]

Cell Line: HepG-2 cells
Concentration: 0.94, 1.88, 3.76 μM
Incubation Time: 48 h
Result: Inhibited the migration of HepG-2 cells.
分子量

546.45

Formula

C29H28BrN3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tubulin/VEGFR-2-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tubulin/VEGFR-2-IN-1Microtubule/TubulinVEGFRReactive Oxygen Species (ROS)ApoptosisVascular endothelial growth factor receptorHepG-2apoptosiscancerTubulinInhibitorinhibitorinhibit

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