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UCL 2077 

目录号: HY-108592
产品使用指南

UCL 2077是sAHP 通道的选择性抑制剂 (海马神经元中的IC50 值为 500 nM),对Ca2+通道、动作电位、输入电阻以及超极化后的介质影响很小。UCL 2077也是具有亚型选择性的、癫痫相关的KCNQ通道的阻滞剂。

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UCL 2077 Chemical Structure

UCL 2077 Chemical Structure

CAS No. : 918311-87-2

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Description

UCL 2077 is a selective slow-afterhyperpolarization (sAHP) channel blocker (IC50 = 500 nM in hippocampal neurons in culture), having minimal effects on Ca2+ channels, action potentials, input resistance and the medium after hyperpolarization[1]. UCL 2077 is also a subtype-selective blocker of the epilepsy associated KCNQ channels[2].

IC50 & Target

sAHP[1].

Molecular Weight

350.46

Formula

C₂₅H₂₂N₂

CAS No.

918311-87-2

SMILES

C1(CNC(C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)=CC=CN=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

UCL 2077UCL2077UCL-2077OthersInhibitorinhibitorinhibit

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产品名称:
UCL 2077
目录号:
HY-108592
需求量: