1. Acids and Aldehydes
  2. Vanillylmandelic acid

Vanillylmandelic acid 

目录号: HY-113121
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Vanillylmandelic acid 是肾上腺素和去甲肾上腺素代谢的最终产物。Vanillylmandelic acid 也可作为神经递质代谢紊乱的标志物。Vanillylmandelic acid 具有抗氧化 (antioxidant) 活性,清除 DPPH 自由基的 IC50 值为 33 μM。

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Vanillylmandelic acid Chemical Structure

Vanillylmandelic acid Chemical Structure

CAS No. : 55-10-7

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Description

Vanillylmandelic acid is the endproduct of epinephrine and norepinephrine metabolism. Vanillylmandelic acid can be used as an indication of the disorder in neurotransmitter metabolism as well. Vanillylmandelic acid has antioxidant activity towards DPPH radical with an IC50 value of 33 μM[1].

In Vitro

Vanillylmandelic acid has antioxidant activity, the IC50 value is determined as the amount of VMA required to reduce 50% of the starting concentration of free radical is 33*10-6 M in the UV-Vis decolourisation DPPH assay[1].

In Vivo

Vanillylmandelic acid (intra-arterial injection over 1 min; 1, 10 and 100 mg/kg; the 60 min-observation period) produces a significant difference between vanillylmandelic acid groups and controls. Vanillylmandelic acid decreases the heart rate by 17.5%, 17.9% and 18.9% after 1, 10 and 100 mg/kg, respectively. Mean blood pressure is decreased by 13.5% in control animals as compared to 37%, 23% and 26% after 1, 10 and 100 mg/kg, respectively, in wistar rats[1].

Molecular Weight

198.17

Formula

C₉H₁₀O₅

CAS No.

55-10-7

中文名称

香草扁桃酸;3-甲氧基-4-羟基扁桃酸

SMILES

O=C(O)C(O)C1=CC=C(O)C(OC)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Vanillylmandelic acidOthersantioxidantDPPHInhibitorinhibitorinhibit

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HY-113121
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