2. Anti-infection
  3. Fungal
  4. VT-1598

VT-1598 是一种口服有效、选择性的真菌抑制剂，靶向 CYP51。VT-1598 具有对白色念珠菌的抗真菌活性。

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VT-1598 Chemical Structure

VT-1598 Chemical Structure

CAS No. : 2089320-99-8

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规格 价格 是否有货 数量
1 mg ￥1727
In-stock
5 mg ￥3800
In-stock
10 mg ￥6200
In-stock
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of VT-1598:

VT-1598 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VT-1598 is an orally active and selective fungal inhibitor targeting CYP51. VT-1598 shows anti-fungal activity against Candida auris[1][2]. VT-1598 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

体外研究
(In Vitro)

VT-1598 (0.015-8 μg/mL; 24 h) 对临床念珠菌 (C. auris) 具有体外抑制活性[1]。
VT-1598 (0.03125-0.125 μg/mL; 24 h) 对临床念珠菌 (C. auris) 的体外生长有显著抑制作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VT-1598 相关抗体:

Cell Viability Assay[1]

Cell Line: 100 C. auris isolates
Concentration: 0.015-8 μg/mL
Incubation Time: 24 hours
Result: Showed MICs ranging from 0.03 to 8 μg/ mL against all isolates, with MIC50 and MIC90 values of 0.25 and 1 μg/mL, respectively.

Cell Viability Assay[2]

Cell Line: 28 Candida isolates obtained from mucosal sites of APECED patients
Concentration: 0.03125-0.125 μg/mL
Incubation Time: 24 hours
Result: Demonstrated potent in vitro activity against all 28 isolates (MIC range=0.03125-0.125 mg/L), with the MIC50 and MIC90 values of 0.0625 and 0.125 mg/L, respectively.
体内研究
(In Vivo)

VT-1598 (口服灌胃; 5, 15, and 50 mg/kg; 每天一次; 7 天) 处理小鼠，使其呈剂量依赖性的生存优势，VT-1598 还剂量依赖性降低小鼠体内的真菌负荷量[1]。
VT-1598 (口服灌胃; 3.2, 8, and 20 mg/kg; 每天一次; 4 天) 在感染白色念珠菌 (C. albicans) 的 Act1 缺陷小鼠的血浆和舌中大量存在[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice model of invasive candidiasis[1]
Dosage: 5, 15, and 50 mg/kg
Administration: Oral gavage; once daily; 7 days
Result: Observed median survival in the VT-1598 15 mg/kg and 50 mg/kg groups (15 days and >21 days, respectively) longer than the control group.
Observed kidney fungal burden in mice treated with 15 mg/kg and 50 mg/kg doses (mean log10 CFU/g, 5.40 and 3.67, respectively) lower than the vehicle control group.
Showed mean trough concentrations 1.55 μg/mL after 7 days of therapy in the 5 mg/kg group, 6.78 μg/mL in the 15 mg/kg group, and 14.2 μg/mL in the 50 mg/kg group.
Animal Model: Act1-deficient mice infected with C. albicans[2]
Dosage: 3.2, 8, and 20 mg/kg
Administration: Oral gavage; once daily; 4 days
Result: Resulted in high concentrations in the plasma and tongues of Candida-infected mice.
Clinical Trial
分子量

584.52

Formula

C31H20F4N6O2
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (171.08 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7108 mL 8.5540 mL 17.1081 mL
5 mM 0.3422 mL 1.7108 mL 3.4216 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

VT-1598 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7108 mL 8.5540 mL 17.1081 mL 42.7701 mL
5 mM 0.3422 mL 1.7108 mL 3.4216 mL 8.5540 mL
10 mM 0.1711 mL 0.8554 mL 1.7108 mL 4.2770 mL
15 mM 0.1141 mL 0.5703 mL 1.1405 mL 2.8513 mL
20 mM 0.0855 mL 0.4277 mL 0.8554 mL 2.1385 mL
25 mM 0.0684 mL 0.3422 mL 0.6843 mL 1.7108 mL
30 mM 0.0570 mL 0.2851 mL 0.5703 mL 1.4257 mL
40 mM 0.0428 mL 0.2139 mL 0.4277 mL 1.0693 mL
50 mM 0.0342 mL 0.1711 mL 0.3422 mL 0.8554 mL
60 mM 0.0285 mL 0.1426 mL 0.2851 mL 0.7128 mL
80 mM 0.0214 mL 0.1069 mL 0.2139 mL 0.5346 mL
100 mM 0.0171 mL 0.0855 mL 0.1711 mL 0.4277 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VT-15982089320-99-8VT1598VT 1598Fungaloral activityanti-fungal activityC. auris isolatesCandida isolatesInhibitorinhibitorinhibit

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