2. Metabolic Enzyme/Protease
  3. Phospholipase
  4. VU 0364739 hydrochloride

VU 0364739 hydrochloride 是一种高选择性的磷脂酶 D2 (PLD2) 抑制剂，对 PLD2 和 PLD1 的 IC50 分别为 20 和 1500 nM。VU 0364739 hydrochloride 诱导细胞凋亡，可用于癌症研究。

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VU 0364739 hydrochloride Chemical Structure

VU 0364739 hydrochloride Chemical Structure

CAS No. : 1244640-48-9

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规格 价格 是否有货 数量
5 mg ￥4601
3 - 4 周
10 mg ￥7366
3 - 4 周
50 mg   询价  
100 mg   询价  

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Customer Review

Other Forms of VU 0364739 hydrochloride:

VU 0364739 hydrochloride 相关抗体

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Phospholipase A PLD

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VU 0364739 hydrochloride is a highly selective phospholipase D2 (PLD2) inhibitor with IC50s of 20 and 1500 nM for PLD2 and PLD1, respectively. VU 0364739 hydrochloride induces apoptosis and it can be used for cancer research[1].

IC50 & Target

PLD2

20 nM (IC50)

PLD1

1500 nM (IC50)

体外研究
(In Vitro)

VU 0364739 (1，5 和 10 μM；24，48，72 和 96 小时) 在无血清条件下时间和剂量依赖性地降低 MDA-MB-231 细胞活力[1]。
VU 0364739 (1，10 和 100 μM；48 小时) 增加 Caspase 3 和 Caspase 7 活性。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VU 0364739 hydrochloride 相关抗体:

Cell Proliferation Assay[1]

Cell Line: MDA-MB-231 cell line
Concentration: 10 μM
Incubation Time: 24 hours
Result: Inhibited cell proliferation of MDA-MB-231 cells.

Apoptosis Analysis[1]

Cell Line: MDA-MB-231 cell line
Concentration: 1, 10 and 100 μM
Incubation Time: 48 hours
Result: Induced cell apoptosis at a dose of 10 μM under serum-free condition or 10% FBS containg condition.
体内研究
(In Vivo)

1.19 Pharmacokinetic Properties of VU 0364739 in Rats[1].

Rats
IV 1 mg/kg		 Rats
PO 10 mg/kg
CL (mL/min/kg) 61.5
t1/2 (h) 1.52
Vdss (L/kg) 8.1
plasma (ng/mL) 39.9
brain (ng/mL) 29

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

482.98

Formula

C26H28ClFN4O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VU 0364739 hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU 03647391244640-48-9VU0364739VU-0364739PhospholipaseselectiveapoptosiscancerratplasmabrainInhibitorinhibitorinhibit

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产品名称：
VU 0364739 hydrochloride
目录号：
HY-108616
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