2. Immunology/Inflammation Anti-infection Metabolic Enzyme/Protease NF-κB Apoptosis MAPK/ERK Pathway PI3K/Akt/mTOR TGF-beta/Smad Stem Cell/Wnt
  3. COX Parasite Reactive Oxygen Species (ROS) Apoptosis p38 MAPK NF-κB Akt mTOR TGF-beta/Smad
  4. Withangulatin A

Withangulatin A 是 COX-2 的抑制剂。Withangulatin A 可抑制 MAPK、NF-κB、Akt/mTOR/p70S6K 通路，具有抗肿瘤、抗炎和杀锥虫活性。

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Withangulatin A

Withangulatin A Chemical Structure

CAS No. : 120824-03-5

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Withangulatin A 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

查看 Parasite 亚型特异性产品:

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 NF-κB 亚型特异性产品:

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 Akt 亚型特异性产品:

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Akt Akt1 Akt2 Akt3

查看 mTOR 亚型特异性产品:

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mTOR mTORC1 mTORC2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Withangulatin A is the inhibitor for COX-2. Withangulatin A inhibits MAPK, NF-κB, Akt/mTOR/p70S6K pathway, exhibits antitumor, anti-inflammatory and trypanocidal activities[1][2][3].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HCT-116 IC50
2.37 μM
Compound: 1; WA
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human HCT-116 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 32886510]
HepG2 IC50
2.85 μM
Compound: 1; WA
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human HepG2 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 32886510]
HK-2 IC50
6.41 μM
Compound: 1; WA
Cytotoxicity against human HK2 cells assessed as cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against human HK2 cells assessed as cell viability incubated for 24 hrs by MTT assay
[PMID: 32886510]
HT-29 IC50
2.48 μM
Compound: 1; WA
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 32886510]
L02 IC50
8.21 μM
Compound: 1; WA
Cytotoxicity against human L02 cells assessed as cell viability incubated for 24 hrs by MTT assay
Cytotoxicity against human L02 cells assessed as cell viability incubated for 24 hrs by MTT assay
[PMID: 32886510]
MCF7 IC50
6.32 μM
Compound: 1; WA
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 24 hrs by MTT assay
[PMID: 32886510]
体外研究
(In Vitro)

Withangulatin A (1.4-5.6 µM, 48 h) 抑制小鼠 T 淋巴细胞增殖，EC50 为 2.89 µM[1]。
Withangulatin A (1.4-5.6 µM, 48 h) 可在小鼠 T 淋巴细胞中降低 LPS (HY-D1056) 诱导的 IL-2、IFN-γ 和 IL-6 分泌，抑制 COX-2 和 PGE2 的表达[1]。
Withangulatin A (0-20 µM, 24 h) 将细胞周期停滞在 S 期，诱导 LX-2 细胞凋亡[2]。
Withangulatin A (0-20 µM, 24 h) 可抑制 TGF-β 刺激的 I 型胶原基因表达，大鼠原代肝星状细胞和 LX-2 细胞中抑制 Smad2/3 的磷酸化和核易位[2]。
Withangulatin A (0-10 µM, 12 h) 可与过氧化物酶 6 (PRDX6) 结合，抑制谷胱甘肽过氧化物酶 (GPx) 和磷脂酶 A2 (iPLA2) 的活性，促进活性氧 (ROS) 的生成[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Withangulatin A 相关抗体:

Cell Proliferation Assay[1]

Cell Line: mouse T lymphocyte
Concentration: 1.4-5.6 µM
Incubation Time: 48 h
Result: Inhibited the proliferation.

Western Blot Analysis[1]

Cell Line: mouse T lymphocyte
Concentration: 1.4-5.6 µM
Incubation Time: 48 h
Result: Reduced the expression of COX-2.

Cell Proliferation Assay[2]

Cell Line: LX-2
Concentration: 0-20 µM
Incubation Time: 24 h
Result: Induced apoptosis.
体内研究
(In Vivo)

Withangulatin A (5-20 mg/kg, ip, once daily for 5 days) 在小鼠 xylene 诱发的耳肿胀模型中表现出抗炎活性[1]。
Withangulatin A (5-10 mg/kg, ip, 3 times a week for 4 weeks) 在小鼠 H1975 异种移植模型中表现出抗肿瘤作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Xylene-induced mouse ear swelling models[1]
Dosage: 5-20 mg/kg
Administration: ip, once daily for 5 days
Result: Inhibited xylene-induced mouse ear swelling.
Reduced the levels of IL-2 and IL-6 in mouse serum.
Animal Model: Mouse H1975 xenograft models[3]
Dosage: 5-10 mg/kg
Administration: ip, 3 times a week for 4 weeks
Result: Inhibited tumor growth.
分子量

526.62

Formula

C30H38O8
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 3 mg/mL (5.70 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.8989 mL 9.4945 mL 18.9890 mL
5 mM 0.3798 mL 1.8989 mL 3.7978 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.76%

COA (302 KB) HNMR (211 KB) LCMS (118 KB)

产品使用指南 (1538 KB)
参考文献

Withangulatin A 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8989 mL 9.4945 mL 18.9890 mL 47.4726 mL
5 mM 0.3798 mL 1.8989 mL 3.7978 mL 9.4945 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Withangulatin A120824-03-5COXParasiteReactive Oxygen Species (ROS)Apoptosisp38 MAPKNF-κBAktmTORTGF-beta/SmadCyclooxygenaseNuclear factor-κBNuclear factor-kappaBPKBProtein kinase BMammalian target of RapamycinTransforming growth factor betacyclooxygenase-2 (COX-2)isolatePhysalis angulata Lanti-tumortrypanocidal activityanti-inflammatoryInhibitorinhibitorinhibit

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