2. Anti-infection
  3. Beta-lactamase
  4. YL6113

YL6113 是一种强效且选择性的金属 β-内酰胺酶 (MBLs) 和丝氨酸 β-内酰胺酶 (SBLs) 双重抑制剂。YL6113 对 MBLs 具有抑制作用，例如 NDM-1、VIM-2、IMP-1，其 IC50 值分别为 0.25、27.16 和 3.55 μM。YL6113 对 SBLs 具有抑制作用，例如 KPC-2、AmpC、OXA-48，其 IC50 值分别为 0.2、34.1 和 1.31 μM。YL6113 能增强美罗培南 (HY-13678) 对碳青霉烯类耐药的革兰氏阴性菌的抗菌效力。YL6113 可用于感染方面的研究。

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YL6113

YL6113 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

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YL6113 相关抗体

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查看 Beta-lactamase 亚型特异性产品:

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Metallo-β-lactamase (MBL) Serine β-lactamase (SBL)

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

YL6113 is a potent and selective dual inhibitor of metallo-β-lactamases (MBLs) and serine-β-lactamases (SBLs). YL6113 shows inhibitory effect to MBLs, such as NDm-1, VIM-2, IMP-1, with IC50 values of 0.25, 27.16 and 3.55 μM. YL6113 shows inhibitory effect to SBLs, such as KPC-2, AmpC, OXA-48, with IC50 values of 0.2, 34.1 and 1.31 μM. YL6113 enhances the antibacterial efficacy of Meropenem (HY-13678) against carbapenem-resistant Gram-negative bacteria. YL6113 can be used for the research of infection[1].

IC50 & Target[1]

KPC-2

0.2 μM (IC50)

NDM-1

0.25 μM (IC50)

OXA-48

1.31 μM (IC50)

IMP-1

3.55 μM (IC50)

VIM-2

27.16 μM (IC50)

AmpC

34.1 μM (IC50)

体内研究
(In Vivo)

YL6113 (10 mg/kg；腹腔注射；单剂量) 与美罗培南 (Meropenem) (HY-13678) 联合使用时，在小鼠脓毒症模型中显著降低了细菌负荷[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Murine sepsis model infected with NDM-1-producing K.p. 140509 strain[1]
Dosage: 10 mg/kg
Administration: Ip, a single dose
Result: Significantly reduced bacterial load in the lungs, liver, and kidneys compared to the control and Meropenem-only groups.
分子量

416.62

Formula

C18H18BClN4O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

YL6113 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YL6113YL 6113YL-6113Beta-lactamaseβ-lactamaseβ-lactamasesNDm-1VIM-2IMP-1KPC-2AmpCOXA-48MeropenemGram-negative bacteriaInhibitorinhibitorinhibit

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产品名称：
YL6113
目录号：
HY-178976
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