2. Membrane Transporter/Ion Channel
  3. Na+/Ca2+ Exchanger
  4. YM-244769 hydrochloride

YM-244769 hydrochloride 

目录号: HY-107659 纯度: 99.02%
COA 产品使用指南

摩尔计算器

YM-244769 hydrochloride 是一种有效的、选择性的、具有口服活性的 Na+/Ca2+ 交换体 (NCX) 抑制剂。YM-244769 hydrochloride 优先抑制 NCX3，抑制 NCX 单向向外电流 (Ca2+ 进入模式)，IC50 分别为 18 nM 和 50 nM。YM-244769 hydrochloride 可有效预防缺氧/复氧诱导的 SH-SY5Y 神经元细胞损伤。YM-244769 hydrochloride 还能增加小鼠的尿量和尿液中电解质的排泄。

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YM-244769 hydrochloride Chemical Structure

YM-244769 hydrochloride Chemical Structure

CAS No. : 837424-39-2

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规格 价格 是否有货 数量
5 mg ￥1600
In-stock
10 mg ￥2600
In-stock
25 mg ￥4900
In-stock
50 mg ￥8500
In-stock
100 mg   询价  
200 mg   询价  

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Customer Review

Other Forms of YM-244769 hydrochloride:

YM-244769 hydrochloride 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

YM-244769 hydrochloride is a potent, selective and orally active Na+/Ca2+ exchanger (NCX) inhibitor. YM-244769 hydrochloride preferentially inhibits NCX3 and suppresses the unidirectional outward NCX current (Ca2+ entry mode), with IC50s of 18 nM and 50 nM, respectively. YM-244769 hydrochloride efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. YM-244769 hydrochloride can also increase urine volume and urinary excretion of electrolytes in mice[1][2][3].

IC50 & Target

IC50: 18 nM (NCX3)[1]
体外研究
(In Vitro)

YM-244769 (0.003-1 μM) inhibits dose dependently the initial rates of 45Ca2+ uptake into NCX1, NCX2, and NCX3 transfectants with IC50 values of 68 ± 2.9, 96 ± 3.5, and 18 ± 1.0 nM, respectively[1].
YM-244769 (0.3 or 1 μM) efficiently protects against the hypoxia/reoxygenation-induced lactate dehydrogenase (LDH) release in SH-SY5Y cells and in LLC-PK1 cells (1 μM)[1].
YM-244769 possesses reverse mode-selectivity[1].
YM-244769 (1 and 10 μM) inhibits NCX current (INCX) in a concentration- and [Na+]i-dependent manner, the IC50 against the unidirectional outward INCX (Ca2+ entry mode) is 0.05 μM. The IC50 values against the bidirectional outward and inward INCX are similar and approximately 100 nM with a Hill coefficient of about 1[3].
YM-244769 is trypsin-insensitive[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

YM-244769 hydrochloride 相关抗体:
体内研究
(In Vivo)

YM-244769 (0.1-1 mg/kg; p.o.; once) exhibits dose-dependently natriuretic action in mice and significantly increased urinary excretion of Ca2+ as well as Ca2+/Cr ratio[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Wild-type C57BL/6J mice and NCX-KO mice[2]
Dosage: 0.1, 0.3 and 1 mg/kg
Administration: Oral administration, once
Result: Caused a dose-dependent increase (up to approximately 200%) in urine volume and urinary excretion of electrolytes (Na+, K+ and Cl-). Natriuretic actions were equivalently observed in NCX1-KO and WT, but disappeared in NCX2-KO and double KO.
分子量

479.93

Formula

C26H23ClFN3O3
CAS 号
性状

固体

颜色

Off-white to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 100 mg/mL (208.36 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.0836 mL 10.4182 mL 20.8364 mL
5 mM 0.4167 mL 2.0836 mL 4.1673 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

YM-244769 hydrochloride 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0836 mL 10.4182 mL 20.8364 mL 52.0909 mL
5 mM 0.4167 mL 2.0836 mL 4.1673 mL 10.4182 mL
10 mM 0.2084 mL 1.0418 mL 2.0836 mL 5.2091 mL
15 mM 0.1389 mL 0.6945 mL 1.3891 mL 3.4727 mL
20 mM 0.1042 mL 0.5209 mL 1.0418 mL 2.6045 mL
25 mM 0.0833 mL 0.4167 mL 0.8335 mL 2.0836 mL
30 mM 0.0695 mL 0.3473 mL 0.6945 mL 1.7364 mL
40 mM 0.0521 mL 0.2605 mL 0.5209 mL 1.3023 mL
50 mM 0.0417 mL 0.2084 mL 0.4167 mL 1.0418 mL
60 mM 0.0347 mL 0.1736 mL 0.3473 mL 0.8682 mL
80 mM 0.0260 mL 0.1302 mL 0.2605 mL 0.6511 mL
100 mM 0.0208 mL 0.1042 mL 0.2084 mL 0.5209 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YM-244769837424-39-2YM244769YM 244769Na+/Ca2+ ExchangerSH-SY5Y cellsneuroprotectivenicotinamideLLC-PK1 cellsNa+/Ca2+ exchangeanti-ischemicNCX3Inhibitorinhibitorinhibit

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